Results 201 to 210 of about 1,020,955 (264)

The relevance of phenotypic definition in treatment resistant forms of major depressive disorder: a narrative review. [PDF]

Front Pharmacol
Paribello P, Isayeva U, Lazzardi S, Pinna M, Contu M, Meloni A, Pisanu C, Squassina A, Baune BT, Manchia M.   +9 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Detection of an arbitrary number of communities in a block spin Ising model. [PDF]

PLoS One
Ballesteros M, Mena RH, Pèrez JL, Toth G.   +3 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Provider and patient perspectives on the diagnosis and treatment of Alzheimer's disease: A global perspective from the Global Alzheimer's Leadership Series (GoALS). [PDF]

Alzheimers Dement
Amouyel P, Andrieu S, Bradshaw A, Carmona RC, Dumont M, Grinberg LT, Iwatsubo T, Hansson O, Jack CR, Jicha GA, Mahinrad S, McDade E, Mummery CJ, Petersen RC, Robinson S, Schneider JA, Shellcross L, Smith AG, Snyder HM, Tapply B, Teunissen C, van der Flier WM, Vellas B, Wallon D, Williamson JD, Wilcock D, Carrillo MC.   +26 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A novel belief-degree-based uncertain Tchebycheff norm DEA model for the case study of risks prioritizing in e-business projects. [PDF]

Sci Rep
Shahbazi M, Rajaei HT, Askarifar K, Mahmoodirad A, Niroomand S.   +4 more
europepmc   +1 more source

Great Saphenous Vein Availability in Lower‑Extremity Arterial Disease: Analysis of a Prospectively Mapped Nonselective Cohort. [PDF]

Vasc Specialist Int
Lee S, Kim J, Jeon Y, Kim HK.
europepmc   +1 more source

Stable Boundaries of Opinion Dynamics in Heterogeneous Spatial Complex Networks. [PDF]

Entropy (Basel)
Bierwirth M, Lengler J.
europepmc   +1 more source

Determining a Real-world Definition of Percutaneous Tibial Nerve Stimulation Induction Therapy in Medicare Beneficiaries With Overactive Bladder. [PDF]

Urology
Nseyo U, Wang L, Crow A, Shatkin-Margolis A, Zuo S, Boscardin WJ, Suskind AM.   +6 more
europepmc   +1 more source