Results 91 to 100 of about 2,431,785 (301)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Russian company investment project valuation with the built-in abandon option
Путеводитель предпринимателя, 2020 This paper is dedicated to development of models and numerical methods for evaluating investment projects of Russian companies using the real options model. In the current economic conditions, it is highly necessary to properly reflect the flexibility of
D. V. Vorotnikova +2 more
doaj
An R&D Investment Game under Uncertainty in Real Option Analysis [PDF]
One of the problems of using the financial options methodolgy to analyse investment decisions is that strategic considerations become extremely important.
Giovanni Villani
core
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Strategic Decision Making Under Uncertainty: Innovation and New Technology Introduction during Volatile Times1 [PDF]
Deere and Company, uncertainty, real option, organizational structure, option, risk, innovation, Industrial Organization, Risk and Uncertainty, Q1,
Boehlje, Michael, Roucan-Kane, Maud
core +1 more source
On Reject and Refine Options in Multicategory Classification
, 2017 In many real applications of statistical learning, a decision made from misclassification can be too costly to afford; in this case, a reject option, which defers the decision until further investigation is conducted, is often preferred. In recent years,
Qiao, Xingye, Wang, Wenbo, Zhang, Chong
core +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Real Option Games with R&D and Learning Spillovers [PDF]
We model pre-investment R&D decisions in the presence of spillover effects in an option pricing framework with analytic tractability. Two firms face two decisions that are solved for interdependently in a two-stage game. The first-stage decision is: what
Martzoukos, Spiros H +1 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source