Results 231 to 240 of about 29,012,891 (356)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The development and pilot testing of a shared decision-making encounter aid for weight management decisions. [PDF]

Obes Pillars
Abu Dabrh AM, Gala KS, Yu J, Najlis ET, Plebani M, Hurtado Andrade MD, Hargraves IG, Clark JE, Ganz ML, Ames GE, Elli EF, White RO, Pantin SL, Acosta A, Brito JP.   +14 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Quality of Large Language Model-Generated MCQs Across Three Medical Disciplines: An Expert Rater-Based Comparison of Gemini, GPT-4 and Perplexity Pro. [PDF]

Adv Med Educ Pract
Mitra NK, Vishnumukkala T, Win TT, Amirthalingam SD, Kwa SK, Thangarasu G, Sumera A, Kandiah S.   +7 more
europepmc   +1 more source

Fuzzy Valuation in Real Options Analysis

Proceedings of the Fuzzy System Symposium, 2009
Zhang, Hui Ming, Lin, Pei-Chun, Wu, Berlin, Watada, Junzo   +3 more
openaire   +1 more source

Quantifying the value of investing in distributed natural gas and renewable electricity systems as complements: Applications of discounted cash flow and real options analysis with stochastic inputs

, 2016
J. Pless, D. Arent, J. Logan, J. Cochran, O. Zinaman   +4 more
semanticscholar   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Development and validation of a human-supervised AI-augmented living oncology evidence platform: a breast cancer pilot study. [PDF]

ESMO Real World Data Digit Oncol
Rugo H, Forsythe A, Flora D, Glück S, Grieve S, Campden R, Liu RJ, Musat M, Rege JM, Kaufman PA, Coleman RL, Tarantino P, O'Shaughnessy J, Schwartzberg L.   +13 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source