Results 271 to 280 of about 3,428,091 (391)

Real-world clinical characteristics and outcomes of patients with locally advanced, unresectable esophageal/gastroesophageal junction cancer treated with definitive chemoradiotherapy in the United States community oncology setting. [PDF]

Front Oncol
Valderrama A, Ramakrishnan K, Herms L, Latimer H, Shi J, Patton G, Bordia S, Nallapareddy S.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Context matching is not reasoning when performing generalized clinical evaluation of generative language models. [PDF]

NPJ Digit Med
Wen A, Lu Q, Chuang YN, Wang G, Yuan J, Zhang J, Wang L, Fu S, Miller KD, Jia H, Bedrick SD, Hersh WR, Roberts KE, Hu X, Liu H.   +14 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Real-world evidence for immunotherapy in the first-line or subsequent-line setting in extensive-stage small-cell lung cancer. [PDF]

Ther Adv Med Oncol
Ren R, Wang Y, Wang Q, Lu B, Gao Y, Li H, Zhang H, Zhang Y, Zhang T.   +8 more
europepmc   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Impact of Computational Histology AI Biomarkers on Clinical Management Decisions in Non-Muscle Invasive Bladder Cancer: A Multi-Center Real-World Study. [PDF]

Cancers (Basel)
Packiam VT, Ghodoussipour S, Konety BR, Ahmadi H, Agarwal G, Kiedrowski LA, Krishna V, Joshi A, Williams SB, Smith AK.   +9 more
europepmc   +1 more source

A real option analysis for stochastic disease control and vaccine stockpile policy: An application to H1N1 in Korea

, 2015
Hojeong Park
openalex   +2 more sources

Innovation subsidies versus consumer subsidies: A real options analysis of solar energy

, 2016
Kiran Torani, G. Rausser, D. Zilberman
semanticscholar   +1 more source