Results 121 to 130 of about 4,215,956 (300)
Life-cycle saving, limits on contributions to DC pension plans, and lifetime tax benefits [PDF]
This paper analyzes questions related to defined contribution (DC) plans. For what types of households are statutory contribution limits likely to bind?
Jagadeesh Gokhale +2 more
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Business Plan Oliveras Real Estate
, 2022 Aquest Treball Fi de Grau té per finalitat l’elaboració d’un pla d’empresa (o business plan en anglès) pel projecte de creació d’una agència immobiliària amb serveis de PSI (Personal Shopper Immobiliari) a Girona que anomenarem Oliveras Real Estate i que tindrà com a mercat les comarques gironines.
openaire +1 more source
Future Productivity Growth in Canada and Implications for the Canada Pension Plan [PDF]
This is organized into three main parts. The first section provides a perspective on future productivity growth in Canada. It discusses key productivity concepts, looks at current productivity trends, examines the forces affecting future productivity ...
Andrew Sharpe
core
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Conditions When the Problems of Linear Programming Are Algorithmically Unsolvable
AxiomsWe study the properties of the constructive linear programming problems. The parameters of linear functions in such problems are constructive real numbers.
Viktor Chernov, Vladimir Chernov
doaj +1 more source
Defined Benefit versus Defined Contribution Pension Plans: What are the Real Tradeoffs? [PDF]
Defined Benefit and Defined Contribution plans have significantly different characteristics with respect to the risks faced by employers and employees, the sensitivity of benefits to inflation, the flexibility of funding, and the importance of ...
Alan J. Marcus +2 more
core
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source