Results 91 to 100 of about 1,495,511 (374)

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

The anterior nucleus of the thalamus plays a role in the epileptic network

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2010-2024, December 2022., 2022
Abstract Objectives We investigated both the metabolic differences and interictal/ictal discharges of the anterior nucleus of the thalamus (ANT) in patients with epilepsy to clarify the relationship between the ANT and the epileptic network. Methods Nineteen patients with drug‐resistant epilepsy who underwent stereoelectroencephalography were studied ...
Hao Yan, Xueyuan Wang, Tao Yu, Duanyu Ni, Liang Qiao, Xiaohua Zhang, Cuiping Xu, Wei Shu, Yuping Wang, Liankun Ren   +9 more
wiley   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Projective product spaces

, 2009
Let nbar=(n_1,...,n_r). The quotient space P_nbar:=(S^{n_1} x...x S^{n_r})/(x ~ -x)is what we call a projective product space. We determine the integral cohomology ring and the action of the Steenrod algebra.
Davis, Donald M.
core   +1 more source

Graph C*-algebras and Z/2Z-quotients of quantum spheres

, 2003
We consider two Z/2Z-actions on the Podles generic quantum spheres. They yield, as noncommutative quotient spaces, the Klimek-Lesniewski q-disc and the quantum real projective space, respectively. The C*-algebras of all these quantum spaces are described
Brzeziński, Cuntz, Ellwood, Fowler, Hajac, Hong, Klimek, Masuda, Piotr M. Hajac, Podleś, Rainer Matthes, Vaksman, Vaksman, Vaksman, Wegge-Olsen, Wojciech Szymański, Woronowicz   +16 more
core   +1 more source

On Real Projective Spaces as Finsler Manifolds [PDF]

Proceedings of the American Mathematical Society, 1967
Let M be a finite-dimensional C3 manifold supplied with a C2 Finsler metric ds = F(x, dx), which is not necessarily even in dx. Let p designate the induced oriented topological metric. For any p E M, the antipodal locus of p is the set A(p)= {qEMIp(p, q)_p(p, r) for all rEM}.
openaire   +2 more sources

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

On the stable homotopy of the real projective space of even low dimension

, 1986
We denote by {X, Y] the group of stable homotopy classes of mappings from X to Y. We denote by P the real n-dimensional projective space. The purpose of this note is to determine the group structure of {P, P} for 2^ng4 (Theorems 2.4, 3.4 and 5.6).
J. Mukai
semanticscholar   +1 more source