Results 131 to 140 of about 116,663 (322)

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

open access: yesAdvanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso   +5 more
wiley   +1 more source

Smooth structures on a fake real projective space

open access: yesTopology and its Applications, 2016
We show that the group of smooth homotopy $7$-spheres acts freely on the set of smooth manifold structures on a topological manifold $M$ which is homotopy equivalent to the real projective $7$-space. We classify, up to diffeomorphism, all closed manifolds homeomorphic to the real projective $7$-space.
openaire   +3 more sources

Étude géométrique et topologique du flot géodésique sur le groupe des rotations [PDF]

open access: yesSurveys in Mathematics and its Applications, 2016
The aim of this survey paper is to investigate the algebraic complete integrability of Euler-Arnold's body description of the four dimensional rigid body, or equivalently of geodesics in SO(4) using left-invariant metrics that arise from inertia tensors,
Ahmed Lesfari
doaj  

Mechanochemical Synthesis and Characterization of Nanostructured ErB4 and NdB4 Rare‐Earth Tetraborides

open access: yesAdvanced Engineering Materials, Volume 27, Issue 6, March 2025.
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur   +5 more
wiley   +1 more source

Real projective space as a space of planar polygons

open access: yes, 2015
We prove that real projective space RP^{n-3} is homeomorphic to the space of all isometry classes of n-gons in the plane with one side of length n-2 and all other sides of length 1. This makes the topological complexity of real projective space more relevant to robotics.
openaire   +2 more sources

Revisiting Stability Criteria in Ball‐Milled High‐Entropy Alloys: Do Hume–Rothery and Thermodynamic Rules Equally Apply?

open access: yesAdvanced Engineering Materials, Volume 27, Issue 6, March 2025.
The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez   +5 more
wiley   +1 more source

A Case‐Based Reasoning Approach to Model Manufacturing Constraints for Impact Extrusion

open access: yesAdvanced Engineering Materials, EarlyView.
A hybrid modeling approach is presented that combines constraint‐based process modeling and case‐based reasoning. The model formalizes manufacturing constraints and integrates simulation data to model complex manufacturing processes. The approach supports manufacturability analysis during product design through an adaptive modeling environment.
Kevin Herrmann   +5 more
wiley   +1 more source

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