Results 61 to 70 of about 118,453 (329)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Immersions of real projective spaces into complex projective spaces
Hiroshima Mathematical Journal, 1987 This paper achieves a classification up to regular homotopy of immersions from a real projective space \(P^ n({\mathbb{R}})\) into a complex projective space \(P^ m({\mathbb{C}})\). Calculations with characteristic classes show that, for \(n>m\), any such immersion is nullhomotopic.
openaire +2 more sources
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
European Physical Journal C: Particles and Fields, 2019 Massless spinning particle model that interacts with electromagnetic and antisymmetric gauge fields in anti-de Sitter space-time is considered as a constrained Hamiltonian system.
D. V. Uvarov
doaj +1 more source
On real analytic Banach manifolds
, 2008 Let $X$ be a real Banach space with an unconditional basis (e.g., $X=\ell_2$ Hilbert space), $\Omega\subset X$ open, $M\subset\Omega$ a closed split real analytic Banach submanifold of $\Omega$, $E\to M$ a real analytic Banach vector bundle, and ${\Cal A}
Patyi, Imre, Simon, Scott
core +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
A Nondesuspension Theorem for Stunted Real Projective Spaces [PDF]
Proceedings of the American Mathematical Society, 1978 For certain stunted projective spaces P and positive integers n, it is shown that P cannot be homotopy equivalent to the n-fold suspension of some other complex.
Davis, Donald M., Mahowald, Mark
openaire +2 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Correction to “Fixed Points of Maps of a Nonaspherical Wedge”
Fixed Point Theory and Applications, 2010 In the original paper, it was assumed that a selfmap of X=P∨C, the wedge of a real projective space P and a circle C, is homotopic to a map that takes P to itself.
Seungwon Kim +4 more
doaj +1 more source