Results 61 to 70 of about 10,663,557 (255)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

‘New’ literacies: technologies and values ‘New’ literacies: technologies and values

Revista Teknokultura, 2012
It is too easy to make light of ‘new literacies’ by saying things like: “Well, there are always newer ones coming along”. Such remarks suggest new literacies have a similar kind of life trajectory to an automobile: new in 2009, semi-new in 2010, and old ...
Michele Knobel, Colin Lankshear
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A Framework for Experimenting Co-creation in Real-Life Contexts

, 2021
The chapter describes the methodology applied throughout the experimentation, the application of co-design, the tools used and their role briefly illustrating the single cases.
Marion Real, Felicitas Schmittinger, Schmittinger, Felicitas, Real, Marion   +3 more
core   +1 more source

A real space Moiré inversion technique and its practical applications in real space for lattice reconstruction

Theoretical and Applied Mechanics Letters
Distinct physical properties emerge at the nanoscale in Moiré materials, such as bilayer graphene and layered material superposition. This study explores similar structural features within a second-generation nickel-based superalloy, unveiling potential ...
Bo Cui, Hongye Zhang, Miao Li, Dong Zhao, Huimin Xie, Zhanwei Liu   +5 more
doaj   +1 more source

Magnetic anomalies of the NW Iberian continental margin and the adjacent abyssal plains

Journal of Maps, 2020
The NW Iberian margin is a hyperextended continental margin, formed during the opening of the North Atlantic Ocean, where a subsequent partial tectonic inversion has undergone during the Alpine Orogeny. This succession of tectonic episodes determines the
María Druet, Manuel Catalán, José Martín-Dávila, Yasmina M. Martos, Alfonso Muñoz-Martín, José Luis Granja-Bruña, Adolfo Maestro   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Real hypersurfaces with constant totally real sectional curvature in a complex space form [PDF]

, 2000
summary:We characterize real hypersurfaces with constant holomorphic sectional curvature of a non flat complex space form as the ones which have constant totally real sectional ...
Pérez, Juan de Dios, Ortega, Miguel, Suh, Young Jin   +2 more
core   +1 more source

EFFECT OF THE X5.4 CLASS SOLAR FLARE EVENT OF SOLAR CYCLE 24 ON THE GPS SIGNAL RECEPTION IN PENINSULAR MALAYSIA [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2016
In this paper, we examine the effect of solar flare event on the Global Positioning System (GPS) signal reception in Peninsular Malaysia during the X5.4 class solar flare on 7th March 2012, 00:24 UT at active region AR1429.
S. Ismail, T. A. Musa, W. A. W. Aris, G. Gopir   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source