Results 91 to 100 of about 6,185,437 (319)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

MDARTS: A Multiprocessor Database Architecture for Real-Time Systems

, 2007
Some of the advanced real-time systems being proposed, such as the Next Generation Workstation/Machine Controller (NGC) for automated factories, require a built-in database to support concurrent data access and provide well-defined interfaces between ...
Real-Time Computing Laboratory
core  

RTXlet: uma abordagem de tempo real para aplicações de tv digital baseadas em Xlets [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-graduação em Engenharia ElétricaEste trabalho propõe uma nova abordagem para aplicações de TV Digital.
Hartke Neto, Roberto
core  

PERTS: A Prototyping Environment for Real-Time Systems

, 1993
PERTS is a prototyping environment for real-time systems. It is being built incrementally and will contain schedulers and resource access protocols for time-critical applications, together with tools and a simulation environment for the analysis ...
Ha, R., Real-Time Systems Symposium, 1993., Proceedings.1-3 Dec. 1993 Page(s):184 - 188, Shih, W.K., Silberman, A., Bettati, R., Storch, M., Too-seng Tia, Ami Silberman, Jane W. S. Liu, Redondo, J.L., Juan-Luis Redondo, Zhong Deng, Rhan Ha, Riccardo Bettati, Wei-kuan Shih, Deng, Z., Matthew Storch, Tia, T.S., Liu, J.W.S.   +18 more
core   +1 more source

Real-Time Spaceborne Synthetic Aperture Radar Float-Point Imaging System Using Optimized Mapping Methodology and a Multi-Node Parallel Accelerating Technique

Sensors, 2018
With the development of satellite load technology and very large-scale integrated (VLSI) circuit technology, on-board real-time synthetic aperture radar (SAR) imaging systems have facilitated rapid response to disasters.
Bingyi Li, Hao Shi, Liang Chen, Wenyue Yu, Chen Yang, Yizhuang Xie, Mingming Bian, Qingjun Zhang, Long Pang   +8 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source