Results 191 to 200 of about 9,656 (245)

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Development of a nurse-led clinical pathway to prevent delirium in older adults in general hospital wards: a realist review protocol. [PDF]

BMJ Open
Hoch J, Müller M, Unger I, Mitzkat A, Denninger NE.   +4 more
europepmc   +1 more source

Structural Eigenmodes of the Brain to Improve the Source Localization of EEG: Application to Epileptiform Activity

Advanced Science, EarlyView.
Geometry and connectivity are complementary structures, which have demonstrated their ability to represent the brain's functional activity. This study evaluates geometric and connectome eigenmodes as biologically informed constraints for EEG source localization.
Pok Him Siu, Philippa J. Karoly, Sina Mansour L., Artemio Soto‐Breceda, Levin Kuhlmann, Mark J. Cook, David B. Grayden   +6 more
wiley   +1 more source

A realist review of how, why, for whom and in which contexts quality improvement in healthcare impacts inequalities. [PDF]

BMJ Qual Saf
Johnson LL, Wong G, Kuhn I, Martin GP, Kapilashrami A, Lennox L, Black GB, Hill M, Swiers R, Mahmood H, Jones L, Beng J, Ford J.   +12 more
europepmc   +1 more source

Stabilization of Single Metal Atoms on Graphitic Carbon Nitride: Synthetic Strategies and Emerging Applications

Advanced Science, EarlyView.
This review highlights recent advancements in stabilizing single metal atoms on graphitic carbon nitride emphasizing innovative synthesis strategies and emerging applications in electrocatalysis, photocatalysis and organic transformations, along with key challenges and future perspective. Abstract Emerging as a new frontier in catalysis science, single‐
Wenyao Zhang, Junjie Cui, Zhenjie Yao, Boyuan Zhu, Nithinraj Panangattu Dharmarajan, Ajayan Vinu, Junwu Zhu   +6 more
wiley   +1 more source

Balancing realist review outputs with the needs of policymakers and practitioners. [PDF]

Health Policy Plan
Mukumbang FC, Klingberg S, Adhikari B.
europepmc   +1 more source

Enhancing nursing and other healthcare professionals' knowledge of childhood sexual abuse through self-assessment: A realist review. [PDF]

Cochrane Evid Synth Methods
Adisa O, Tyrrell K, Allen K.
europepmc   +1 more source

What are the Mechanisms and Contexts for a Supported Life After Stroke Pathway: Protocol for a Rapid Realist Review. [PDF]

HRB Open Res
Lennon O, O'Neill M, Walsh K, Horgan F.
europepmc   +1 more source

A realist review of factors critical for the implementation of eHealth in chronic disease management. [PDF]

BMC Health Serv Res
Shahid N, Parker G, Bielecki JM, Rac V, Berta W.   +4 more
europepmc   +1 more source