Advanced Science, EarlyView.A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son +2 more
wiley +1 more source
AI-Driven Internet of Things (IoT) dataset for remote health monitoring and fall detection in elderly people. [PDF]
Data BriefIslam MR, Patwary MO, Islam SMA.
europepmc +1 more source
Analysis of meaningful reading in the 5th year of elementary school, from a realistic perspective
Maria Leane de Lima +6 more
openalex +2 more sources
Robert Alexy, fundamental rigths, legal speach and practical rationality. ¿A realistic reading?
, 2017 El presente artículo se centra en el análisis de la literatura producida por Robert Alexy, reconocido jurista alemán, centrada en el concepto de los derechos fundamentales los cuales son, en un estado constitucional de derecho, el fin último del ordenamiento jurídico.
openaire +1 more source
A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions
Advanced Science, EarlyView.This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies +14 more
wiley +1 more source
Bridging the gap: A scoping review of wet and dry lab simulation training in orthopaedic surgical education. [PDF]
World J OrthopAl Hajaj SW +6 more
europepmc +1 more source
Advanced Science, EarlyView.Geometry and connectivity are complementary structures, which have demonstrated their ability to represent the brain's functional activity. This study evaluates geometric and connectome eigenmodes as biologically informed constraints for EEG source localization.
Pok Him Siu +6 more
wiley +1 more source
Aurally impressed, yet not more stressed: On the relationship between audiovisual realism, social anxiety, and presence in a virtual social stress scenario. [PDF]
PLoS OneRoßkopf S +5 more
europepmc +1 more source
Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain
Advanced Science, EarlyView.A new approach uses simple neural networks to create digital twins of brain activity, capturing how different patterns unfold over time. The method generates and recovers key dynamics even from noisy data. When applied to fMRI, it predicts brain signals and reveals distinctive activity patterns across regions and individuals, opening possibilities for ...
Gabriele Di Antonio +3 more
wiley +1 more source
OSCEai: personalized interactive learning for undergraduate medical education. [PDF]
Can Med Educ JGuo E, Ramchandani R, Park YJ, Gupta M.
europepmc +1 more source