Results 71 to 80 of about 3,092 (216)
Gene therapy: Myth or reality?
Comptes Rendus. Biologies, 2016 Gene therapy has become a reality, although still a fragile one. Clinical benefit has been achieved over the last 17 years in a limited number of medical conditions for which pathophysiological studies determined that they were favorable settings. They include inherited disorders of the immune system, leukodystrophies, possibly hemoglobinopathies ...
openaire +2 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Jurnal Kajian Bimbingan dan Konseling, 2018 : This research and development aims to produce a cybercounseling reality website and a reality cybercounseling guidebook to improve self-disclosure for Vocational High School students which are grateful theoretically and practically.
Abi Fa'izzarahman Prabawa +2 more
doaj
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Iranian Journal of Educational ResearchObjective: The objective of the present investigation was to assess the efficacy of reality therapy and emotion-focused therapy in mitigating cognitive avoidance among women experiencing marital distress.
Maryam Toope +2 more
doaj
Comparison between the effects of group-based acceptance and commitment therapy and group-based reality therapy on work-family conflict & psychological well-being of married female staffs [PDF]
مجله علمی دانشگاه علوم پزشکی کردستان, 2019 Background and Aim: Administration of the therapy protocols can increase psychological well-being with resultant decrease in the work-family conflict. The purpose of this study was to make a comparison between the effects of group-based acceptance and ...
Hajikaram A, Ghamari M, Amiri Majd M
doaj
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Development and validation of the couple’s basic needs assessment scale
مجله علوم روانشناختی, 2019 Background: The focus of reality therapy interventions in working with couples, is to raise couple’s awareness of their needs and to help them meet each other’s needs.
mona maaref +3 more
doaj
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source