Results 231 to 240 of about 3,262,397 (309)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Camp of Reason: Spinoza's Ethics as Affirmative Excess. [PDF]

Nurs Philos
Smith JB.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Approaches to quantifying acceptability of pharmaceutical interventions for neglected tropical diseases: A scoping review. [PDF]

PLoS Negl Trop Dis
Duguay C, Ost K, Krentel A.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Reasons for contraceptive nonuse at two sites in Burkina Faso. [PDF]

Contraception
Senderowicz L, Romell E, Bullington BW, Sawadogo N, Tumlinson K.   +4 more
europepmc   +1 more source

Breeding objectives and trait prioritization in indigenous goat systems: insights from South African smallholders. [PDF]

Trop Anim Health Prod
Ntonga SP, Mpetile Z, Mpendulo CT, Akinmoladun OF.   +3 more
europepmc   +1 more source

Religion within reason

, 2017
Cahn, Steven M.
core  

Pediatric dental treatment under general anesthesia: a retrospective analysis of clinical indications and a survey of pediatric dentist referral practices. [PDF]

Front Dent Med
Fux-Noy A, Raz M, Masrawa K, Shmueli A, Halperson E, Moskovitz M.   +5 more
europepmc   +1 more source