Results 171 to 180 of about 738,099 (298)

Reconceptualizing Clinical Priority as Relational Influence: Derivation of Drawing Reasoning From a Sequential Programme of Research. [PDF]

J Eval Clin Pract
Milani A, Misurelli E, Mazzocco K.
europepmc   +1 more source

Editorial

The Reasoner, 2012
Federica Russo
doaj  

Reason and Reasoning

In the time of Descartes, philosophers on both sides of the English Channel inhabited the same universe of discourse, were concerned with the same range of questions and argued about them in mutually intelligible ways. Descarte's own central concern, of course, was questions ofcertainty, knowledge and truth; as Anthony Kenny has put it, "his whole ...
openaire   +1 more source

Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc1

FEBS Open Bio, EarlyView.
The review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Anna Wójcik‐Augustyn, Artur Osyczka, Marcin Sarewicz   +2 more
wiley   +1 more source

Diagnostic Reasoning in General Internal Medicine Consultations: A Text Mining Analysis of Consultation Requests. [PDF]

J Gen Fam Med
Kawamura R, Harada Y, Shimizu T.
europepmc   +1 more source

Argument Cultures, 3–6 June

The Reasoner
Hans V. Hansen, Christopher W. Tindale, J. Anthony Blair, Ralph H. Johnson   +3 more
doaj  

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

The Alignment Paradox of Medical Large Language Models in Infertility Care: Decoupling Algorithmic Improvement From Clinical Decision-Making Quality. [PDF]

J Med Internet Res
Liu D, Long Y, Zuoqiu S, Liu D, Li K, Xie K, Yang R, Lin Y, Liu H, Yin R, Tang T.   +10 more
europepmc   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Comparative evaluation of large language models for text-based diagnostic reasoning in fetal central nervous system MRI: A retrospective single-center diagnostic accuracy study. [PDF]

Medicine (Baltimore)
Yu R, Peng M, Li H, Liu S, Su T, Guan H, Shen Y, Deng Y, Zhao D.   +8 more
europepmc   +1 more source