Results 111 to 120 of about 8,946,291 (316)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Deflationary Pluralism about Motivating Reasons [PDF]
, 2018 This paper takes a closer look at ordinary thought and talk about motivating reasons, in an effort to better understand how it works. This is an important first step in understanding whether—and if so, how—such thought and talk should inform or constrain
Fogal, Daniel
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Argumentation, Cooperation, and Disagreement
Informal Logic: To get a better comprehension of the nature of argumentation, we need to understand the context in which this practice produces its particular benefits.
Fabian Bernache Maldonado
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Әл-Фараби Атындағы Қазақ Ұлттық Университеті хабаршы шығыстану сериясы, 2016 The paper discusses social processes in the countries of North Africa and the Middle East at the beginning of the XXI century.
Zh. U Myrzagul
doaj
ChildrenExposure to violence is one of the most common adverse effects. In recent years, there has been a particular interest in understanding the link between exposure to violence and the perpetration of other forms of violence, such as child-to-parent violence,
Luis Burgos-Benavides +4 more
doaj +1 more source
Development Perspectives of the Social Group Cohesion in Reducing Social Loafing
Organizacijų Vadyba: Sisteminiai Tyrimai, 2017 The purpose of this research is to elaborate development perspectives of the social group cohesion seeking to reduce the incidence of the phenomenon. The authors analyse theoretical and empirical studies on social loafing and based on this analysis try ...
Vveinhardt Jolita, Banikonytė Justina
doaj +1 more source