Results 111 to 120 of about 605,528 (306)

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Religious Disagreement in Analytic Theology

open access: yesSt Andrews Encyclopaedia of Theology
Religious disagreement means holding incompatible views of the truth or of the plausibility of some position that is religiously relevant. It is well known that many religious and non-religious worldviews make apparently incompatible claims about ...
Olli-Pekka Vainio
doaj  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

open access: yesFEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah   +8 more
wiley   +1 more source

Waarom verskil ons so oor wat die wil van God is? Opmerkings oor Christelike morele oordeelsvorming

open access: yesVerbum et Ecclesia, 1996
Why do we differ so much about the will of God? Comments on the formation of Christian moral judgements A better understanding of the way in which moral judgements are made and moral decisions are taken may help to understand why Christians differ so ...
D. E. de Villiers, D. J. Smit
doaj   +1 more source

The Attempt to Improve Criminal Defense Representation [PDF]

open access: yes, 1977
Improvement of criminal defense representation is one of the most critical problems that faces the criminal justice system. The problem is extensive; some attorneys are frequently ineffective and probably all attorneys are occasionally inadequate because
Tague, Peter W.
core   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

open access: yesFEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart   +4 more
wiley   +1 more source

Reconciling Enkrasia and Higher-Order Defeat [PDF]

open access: yes, 2019
Titelbaum Oxford studies in epistemology, 2015) has recently argued that the Enkratic Principle is incompatible with the view that rational belief is sensitive to higher-order defeat.
Skipper, Mattias
core  

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