Results 131 to 140 of about 605,528 (306)

Can and should the research–therapy distinction be maintained? Reflections in the light of innovative last-resort treatment

open access: yesResearch Ethics Review, 2019
It has been debated for quite some time among bioethicists and others whether or not the distinction between therapy and research in healthcare can and should be maintained.
Gert Helgesson
doaj   +1 more source

Overcoming Expert Disagreement In A Delphi Process. An Exercise In Reverse Epistemology [PDF]

open access: yes, 2015
Disagreement among experts is a central topic in social epistemology. What should an expert do when confronted with the different opinion of an epistemic peer?
Elisabetta, Lalumera
core   +2 more sources

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini   +7 more
wiley   +1 more source

Towards a Transcendental Critique of Feeling (A Response to Grenberg)

open access: yesCon-textos Kantianos: International Journal of Philosophy, 2016
This paper focuses on responding to Jeanine Grenberg’s claim that my discussion of Kant’s feeling of respect leaves no meaningful room for investigating feeling first-personally.
Patrick Frierson
doaj  

Magnification relations of quad lenses and applications on Einstein crosses

open access: yes, 2016
In this work, we mainly study the magnification relations of quad lens models for cusp, fold and cross configurations. By dividing and ray-tracing in different image regions, we numerically derive the positions and magnifications of the four images for a
Chu, Zhe   +3 more
core   +1 more source

The Impact of Tilburg Frailty on Poststroke Fatigue in First‐Ever Stroke Patients: A Cross‐Sectional Study With Unified Measurement Tools and Improved Statistics

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen   +6 more
wiley   +1 more source

An idea of public reason: exclusionary and broad

open access: yesInternational Journal of Philosophy and Social Values
Any conception of public reason that includes a principle of restraint on certain kinds of reasons, making them inadmissible for the purposes of public political justification, has to be specified according to the following characteristics: 1) the ...
Diogo Fernandes
doaj   +1 more source

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini   +13 more
wiley   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez   +12 more
wiley   +1 more source

Schools’ Challenges in Distance Learning during Emergency Education: Focus Group Methodology

open access: yesEducation Sciences
The present research uses the focus group discussion methodology to report the challenges met by the educational system in distance education during emergency education. It shows the different potentialities of this use.
Wajeeh Daher
doaj   +1 more source

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