Results 61 to 70 of about 607,703 (364)

Determinants of Non-Acceptance of the COVID-19 Vaccine During Pregnancy in Pregnant and Postpartum Women: A Descriptive Cross-Sectional Study

Journal of Family and Reproductive Health
Objective: The rate of COVID-19 vaccination hesitation among Iranian pregnant women is around 50%. The objective of the present study was to determine the reasons for the refusal of COVID-19 vaccination among pregnant and postpartum women. Materials and
Maryam Dehshiri, Mehrdad Mansouri, Mohammad Hossein Jarahzadeh, Nooshin Hatamizadeh   +3 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Scientific Disagreement and Evidential Pluralism: Lessons from the Studies on Hypercholesterolemia

Humana.Mente: Journal of Philosophical Studies, 2018
Inconsistencies between scientific theories have been studied, by and large, from the perspective of paraconsistent logic. This approach considered the formal properties of theories and the structure of inferences one can legitimately draw from theories.
Veli-Pekka Parkkinen, Federica Russo, Christian Wallmann   +2 more
doaj  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Theories of Low-Energy Quasi-Particle States in Disordered d-Wave Superconductors

, 2002
The physics of low-energy quasi-particle excitations in disordered d-wave superconductors is a subject of ongoing intensive research. Over the last decade, a variety of conceptually and methodologically different approaches to the problem have been ...
Affleck, Alexander Altland, Altland, Altland, Alvarez, Anderson, Andreev, B.D. Simons, Balatsky, Balents, Berezin, Berline, Bocquet, Bundschuh, Bundschuh, Cardy, Cardy, Chiao, Durst, Dyson, Efetov, Fendley, Franz, Friedan, Fukui, Gorkov, Gorkov, Gruzberg, Guruswamy, Helgason, Hirschfeld, Hussey, Joynt, Kagalovsky, Kaminski, Knizhnik, Kulić, Kulić, Laughlin, Lee, Levine, Li, Ludwig, M.R. Zirnbauer, Marinelli, Melnikov, Monthoux, Moradian, Nagaosa, Nersesyan, Novikov, Orenstein, Polyakov, Pruisken, Read, Senthil, Senthil, Senthil, Senthil, Simon, Verbaarschot, Verbaarschot, Vishveshwara, Volovik, Witten, Ye, Zamolodchikov, Zhang, Ziegler, Zinn-Justin, Zirnbauer   +70 more
core   +1 more source

Model risk of risk models [PDF]

, 2016
This paper evaluates the model risk of models used for forecasting systemic and market risk. Model risk, which is the potential for different models to provide inconsistent outcomes, is shown to be increasing with market uncertainty. During calm periods,
Danielsson, Jon, James, Kevin R., Valenzuela, Marcela, Zer, Ilknur   +3 more
core   +1 more source

Level of agreement between 2002 American–European Consensus Group and 2012 American College of Rheumatology classification criteria for Sjögren’s syndrome and reasons for discrepancies

Arthritis Research & Therapy, 2014
IntroductionThe aims of this study were to assess agreement between the currently used 2002 American–European Consensus Group (AECG) classification criteria and the new 2012 American College of Rheumatology (ACR) criteria for Sjögren’s syndrome (SS) and ...
D. Cornec, A. Saraux, B. Cochener, J. Pers, S. Jousse-Joulin, Yves Renaudineau, T. Marhadour, V. Devauchelle-Pensec   +7 more
semanticscholar   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Disagreement Lost and Found [PDF]

, 2017
According to content-relativist theories of moral language, different speakers use the same moral sentences to say different things. Content-relativism faces a well-known problem of lost disagreement.
Finlay, Stephen
core   +1 more source