Results 71 to 80 of about 605,528 (306)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Coverage of extreme weather events and natural hazards in Pacific Island Countries: The need for media capacity-building

Pacific Journalism Review, 2018
There would be little disagreement over the media’s crucial role in reporting extreme weather events and natural hazards, which have become more commonplace in Pacific Island Countries (PICs).
Shailendra Singh, Vijay Naidu
doaj   +1 more source

Public reason and private bias: Accommodating political disagreement [PDF]

, 2023
Athmeya Jayaram
openalex   +1 more source

Taking Prudence Seriously [PDF]

, 2019
Philosophers have long theorized about which things make people’s lives go well, and why, and the extent to which morality and self-interest can be reconciled.
Fletcher, Guy
core   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Comparison of the modeling results of nitrate concentrations in soil water below the root zone in the local and regional scale

Geologija, 2018
The article presents a comparative analysis of the modeling results of nitrate concentrations in water below the root zone of the soil in the local and regional scale.
Jože Uhan, Mišo Andjelov
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Comparison of Expert Adjudicated Coronary Heart Disease and Cardiovascular Disease Mortality With the National Death Index: Results From the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background The National Death Index (NDI) is widely used to detect coronary heart disease (CHD) and cardiovascular disease (CVD) deaths, but its reliability has not been examined recently.
Olusola Tope Olubowale, Monika M. Safford, Todd M. Brown, Raegan W. Durant, Virginia J. Howard, Christopher Gamboa, Stephen P. Glasser, J. David Rhodes, Emily B. Levitan   +8 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Disagreements in risk of bias assessment for randomized controlled trials in hypertension-related Cochrane reviews

Trials
Background The inter-reviewer reliability of the risk of bias (RoB) assessment lacked agreement in previous studies. It is important to analyse these disagreements to improve the repeatability of RoB assessment. The objective of the study was to evaluate
Yi Yao, Jing Shen, Jianzhao Luo, Nian Li, Xiaoyang Liao, Yonggang Zhang   +5 more
doaj   +1 more source