Results 111 to 120 of about 304,891 (277)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Policing and Transgressing Borders: Soldiers, Slave Rebels, and the Early Modern Atlantic
NWIG, 2009 In 1763, a regiment of mercenary soldiers stationed on the border of Suriname and Berbice in South America, rebelled. The men had been sent to help subdue a large slave rebellion. Instead, they mutinied and joined the rebelling slaves.
Marjoleine Kars
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\u3cem\u3eUnited States v. Hodges\u3c/em\u3e: Treason, Jury Trials, and the War of 1812 [PDF]
, 2016 In August 1814 a number of British soldiers were arrested as stragglers or deserters in the town of Upper Marlboro, Maryland. Upon learning of the soldiers’ absences the British military took local physician, Dr.
Smith, Jennifer Elisa
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Estudios Atacameños, 2002 Este artículo consta de una introducción y de la transcripción del expediente de la rebelión acontecida en Ingaguasi en 1775 (jurisdicción de la provincia de Atacama).
Nelson Castro F +2 more
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ECONOMIC EFFICIENCY VS. DISTRIBUTIVE EQUITY: THE "SAGEBRUSH REBELLION" [PDF]
The purpose of this paper is to interpret, from the viewpoint of an economist, some of the causes of the ‘Sagebrush Rebellion,’ a contemporary land reform movement directed toward the Bureau of Land Management and its control of the public domain ...
Obermiller, Frederick W.
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Destroying the Right Arm of Rebellion: Lincoln’s Emancipation Proclamation
, 2019 Lincoln\u27s Emancipation Proclamation was a gamble. If it were to succeed, it could cripple the economy of the South, decimating its war effort, drive the border states to accept compensated emancipation, ending slavery as an institution in the United ...
Pontz, Benjamin
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Miedo, rumor y rebelión: la conspiración esclava de 1693 en Cartagena de Indias.
Historia Crítica, 2006 This paper examines the reality of slave resistance, particularly rebellion, through a study of the oppressors’ fear and the dominant discourse, focusing on the effects of the rumor of a slave conspiracy in 1693.
Sandra Beatriz Sánchez López.
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