Results 61 to 70 of about 3,678,647 (280)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Supply constraints on rebound effects of increased energy efficiency : negative multiplier and disinvestment effects [PDF]

, 2010
Policies that aim to use increased energy efficiency to reduce energy use may not achieve the desired results due to the likelihood of rebound effects.
Turner, Karen, De Fence, Janine, Swales, Kim, Anson, Sam   +3 more
core   +3 more sources

Recovery of the 20 Hz Rebound to Tactile and Proprioceptive Stimulation after Stroke

Neural Plasticity, 2018
Sensorimotor integration is closely linked to changes in motor-cortical excitability, observable in the modulation of the 20 Hz rhythm. After somatosensory stimulation, the rhythm transiently increases as a rebound that reflects motor-cortex inhibition ...
Eeva Parkkonen, Kristina Laaksonen, Lauri Parkkonen, Nina Forss   +3 more
doaj   +1 more source

Separating Algorithms From Questions and Causal Inference With Unmeasured Exposures: An Application to Birth Cohort Studies of Early Body Mass Index Rebound

American Journal of Epidemiology, 2021
Abstract Observational studies reporting on adjusted associations between childhood body mass index (BMI; weight (kg)/height (m)2) rebound and subsequent cardiometabolic outcomes have often not paid explicit attention to causal inference, including definition of a target causal effect and assumptions for unbiased estimation of that ...
Aris, Izzuddin M., Sarvet, Aaron L., Stensrud, Mats J., Neugebauer, Romain, Li, Ling-Jun, Hivert, Marie-France, Oken, Emily, Young, Jessica G.   +7 more
openaire   +4 more sources

Energy Elasticities and the Rebound Effect: A Comprehensive Empirical Analysis [PDF]

, 2016
In diesem Forschungsprojekt werden aktuelle Preis- und Einkommenselastizitäten für Energie und andere Produktionsfaktoren bzw. Konsumgütergruppen in der Schweiz geschätzt. Im Weiteren wird der Rebound-Effekt für den privaten Transport untersucht.
Müller, Daniel, Mohler, Lukas, Deininger, Sebastian   +2 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Wetting-drying-freezing-thawing cycle effect on the hydro-mechanical behaviour of Yanji swelling mudstone

Journal of Rock Mechanics and Geotechnical Engineering, 2023
Swelling geomaterials in northwestern and northeastern China are exposed to both seasonal wetting-drying (DW) and freezing-thawing (FT) processes. The influence of full-process wetting-drying-freezing-thawing (WDFT) cycles on their hydro-mechanical ...
Zhixiong Zeng, Lingwei Kong
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source