His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models
His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li +13 more
wiley +1 more source
Association of spinal cord structure with cognition in hereditary spastic paraplegia type 5. [PDF]
Chen X +9 more
europepmc +1 more source
RegGAIN is a novel and powerful deep learning framework for inferring gene regulatory networks (GRNs) from single‐cell RNA sequencing data. By integrating self‐supervised contrastive learning with dual‐role gene representations, it consistently outperforms existing methods in both accuracy and robustness.
Qiyuan Guan +9 more
wiley +1 more source
Acute Estradiol Bridges Gut Microbiome Composition With Cognition. [PDF]
Hodes GE, Kropp DR.
europepmc +1 more source
Time‐Efficient and Informatic‐Skill‐Light Gap‐Filling for Telomere‐to‐Telomere Genome Assembly
The paper introduces a novel auxiliary software toolbox GapSuite, consisting of two tools Gap‐Aid and Gap‐Graph, which guides users to fill gaps in chromosome‐level genome assembly using sequence‐extension‐based and assembly‐graph‐based strategies. The two tools enable users with limited informatics expertise to efficiently complete gap‐filling on ...
Dong Xu +8 more
wiley +1 more source
Protein synthesis blockade prevents fear memory reactivation via inhibition of engram synapse strengthening. [PDF]
Hong I +5 more
europepmc +1 more source
A direct test of the hypothesis that amount recalled is determined by degree of clustering
Slaybaugh, Valerie J.
openalex +1 more source
Generating Dynamic Structures Through Physics‐Based Sampling of Predicted Inter‐Residue Geometries
While static structure prediction has been revolutionized, modeling protein dynamics remains elusive. trRosettaX2‐Dynamics is presented to address this challenge. This framework leverages a Transformer‐based network to predict inter‐residue geometric constraints, guiding conformation generation via physics‐based iterative sampling. The resulting method
Chenxiao Xiang +3 more
wiley +1 more source
Cognitive Profiles in Adolescents and Young Adults With Co-Occurring Autism and First-Episode Psychosis: A Preliminary Neuropsychological Investigation. [PDF]
Lau DTY +6 more
europepmc +1 more source

