Results 171 to 180 of about 489,542 (244)

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Role of Flow Cytometry in the Diagnosis of Urinary Tract Infections. [PDF]

Cureus
Trnacevic E, Trnacevic A, Mahmutovic M, Porobic Jahic H, Becirovic A, Selimovic J.   +5 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Latent Supervision: A Method for Improved Performance and Calibration of Machine Learning Classification Models in Ophthalmology. [PDF]

Ophthalmol Sci
Yazbeck H, Assaf J, Lietman TM, Keenan JD, Jackson J, Kalpathy-Cramer J, Campbell JP, Song X, Redd TK.   +8 more
europepmc   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Effects of Exposure to Differentially Stressed Pinus sylvestris Seedlings on the Susceptibility of Receivers to Feeding by the Large Pine Weevil. [PDF]

J Chem Ecol
Mashhadi Meyghani S, Rasheed MU, Blande JD.   +2 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Spatial and Directional Modulation Systems for Near-Field Secure Transmission. [PDF]

Sensors (Basel)
Liu J, Zhong Y, Wang Y, Gong D, Xiao Y.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Structural optimization and performance analysis of the cable-driven fine adjustment mechanism for the new FAST feed cabin. [PDF]

Sci Rep
Zhang L, Sun J, Jiang P, Li H.
europepmc   +1 more source