Results 121 to 130 of about 7,675,652 (304)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

All in One 315 MHz ASK UHF Receiver

, 2014
An all in one integrated 315MHz ASK UHF receiver is proposed in this paper. This receiver is a monolithic ultrahigh frequency (UHF) receiver including radio-frequency (RF) front-end, intermediate-frequency (IF) stage, base-band stage and final filter ...
Lee, Yang-Han; Chen, Jiann-Jong; Huang, Chao-Chung; Shih, Cheng-Ming; Chen, Hsuan-Fan
core  

A variable delay integrated receiver for differential phase-shift keying optical transmission systems [PDF]

, 2012
An integrated variable delay receiver for DPSK optical transmission systems is presented. The device is realized in silicon-on-insulator technology and can be used to detect DPSK signals at any bit-rates between 10 and 15 Gbit ...
Morichetti, F, Sorel, M, Melloni, A, Orlandi, P, Strain, MJ, Ferrari, C, Mattarei, M, Canciamilla, A, Grillanda, S, Bassi, P   +9 more
core   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Quantitative Electroencephalography for Predication of Neurological Dysfunction in Type A Aortic Dissection: A Prospective Observational Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Type A aortic dissection presents challenges with postoperative cerebral complications, and this study evaluates the predictive value of quantitative electroencephalography for perioperative brain function prognosis.
Ya‐peng Wang, Yong‐qing Cheng, Hanghang Wang, Huanhuan Wang, Wen‐xue Liu, Yi Jiang, Yun‐xing Xue, Yang Chen, Qing Zhou, Xuan Luo, Qingxiu Zhang, Jason Zhensheng Qu, Dong‐jin Wang   +12 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

An Fpga-Based Simulation And Implementation Of The Aal Type 2 Receiver

, 2007
This paper describes a hardware implementation of an ATM Adaptation Layer (AAL) type 2 receiver. The simulation performance of the developed prototype is measured with real AAL type 2 encoded material and compared to two software-based AAL type 2 ...
Matti Tommiska Department, Mika Loukola, Tero Koskivirta, Matti Tommiska   +3 more
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