Results 161 to 170 of about 7,675,652 (304)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Determination Of Tec Above Yogyakartaand Watukosek Using Beacon Receiver

, 2015
Some equipment are already being used for TEC measurement and ionospheric scintillation, named Ionosonde, GPS and GPS-RO. Recent equipment that can be used for those research is called beacon receiver, which is simple, less expensive and available ...
Timbul Manik, Peberlin Sitompul, Mario Batubara   +2 more
core  

Tandem receiver domain response regulator DrdR modulates swarming by controlling PilB/PilT activity in <i>Xanthomonas campestris</i>. [PDF]

mLife
Ren P, Meng J, Qin Q, Shi J, Yao J, Qi Y, Tang J, Li RF, Lu GT.   +8 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Cell-Cell Communication in Embryonic Kidney Development: Insights from Single-Cell and Spatial Transcriptomics. [PDF]

J Dev Biol
Wang L, Zheng X, Zhu F, Xiang L, Liu C, Feng E, Liu Y, Dai Y.   +7 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

An FPGA-based Implementation and Simulation of the AAL Type 2 Receiver

, 1999
This paper describes a hardware implementation of an ATM Adaptation Layer #AAL# type 2 receiver. The simulation performance of the developed prototype is measured with real AAL type 2 encoded material and compared to two software-based AAL type 2 ...
Mika Loukola, Tero Koskivirta, Matti Tommiska   +2 more
core  

GNSS Spoofing Detection Method Based on the Pseudorange Difference Between Epochs for Single-Antenna Receivers. [PDF]

Sensors (Basel)
Chen S, Li F, Zhang Z, Zhang Q, Wu H, Dong X.   +5 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Baseline Serum Metabolites as Predictors of Teplizumab Response in Individuals With Type 1 Diabetes. [PDF]

Diabetes
Flammer ER, Higdon LE, Sanda S, Brusko TM, Garrett TJ, Ismail HM.   +5 more
europepmc   +1 more source