Results 131 to 140 of about 2,128 (154)
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Numerical assessment of recellularization conditions to vessel occlusion
Biomechanics and Modeling in Mechanobiology, 2023To ensure the functional properties of an organ generated by the process of decellularization and recellularization, the initial density and distribution of seeding cells in the parenchymal space should be maximized. However, achieving a uniform distribution of cells across the entire organ is not straightforward because of vessel occlusion. This study
Van, Lap Nguyen, Hiromichi, Obara
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Limitations of recellularized biological scaffolds for human transplantation
Journal of Tissue Engineering and Regenerative Medicine, 2020A shortage of donor organs for transplantation and the dependence of the recipients on immunosuppressive therapy have motivated researchers to consider alternative regenerative approaches. The answer may reside in acellular scaffolds generated from cadaveric human and animal tissues.
Claudia Bilodeau +3 more
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Histological structure affects recellularization of decellularized arteries
Materials Science and Engineering: C, 2017Decellularized arteries were prepared to evaluate the in vivo recellularization of biological material after implantation. Porcine aortas and radial arteries were decellularized using high-hydrostatic pressure to form materials with histologically-different structures.
Jun, Negishi +5 more
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Current Opinion in Organ Transplantation, 2014
Allogeneic organ transplantation is burdened by donor shortage, graft rejection and adverse effects of lifelong immune suppression. Engineering bioartificial organs from acellular organ scaffolds and patient-derived cells are a new approach to potentially overcome these limitations.Decellularized organs yield a scaffold of extracellular matrix on which
Philipp T, Moser, Harald C, Ott
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Allogeneic organ transplantation is burdened by donor shortage, graft rejection and adverse effects of lifelong immune suppression. Engineering bioartificial organs from acellular organ scaffolds and patient-derived cells are a new approach to potentially overcome these limitations.Decellularized organs yield a scaffold of extracellular matrix on which
Philipp T, Moser, Harald C, Ott
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Negative Pressure Cell Delivery Augments Recellularization of Decellularized Lungs
Tissue Engineering Part C: Methods, 2021For end-stage lung disease, lung transplantation remains the only treatment but is limited by the availability of organs. Production of bioengineered lungs via recellularization is an alternative but is hindered by inadequate repopulation. We present a cell delivery method via the generation of negative pressure.
Mohammadali, Ahmadipour +4 more
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Decellularization and Recellularization of Cartilage
2017Decellularization of cartilage enables the use of cartilage allografts or xenografts as natural scaffolds for repair and regeneration of injured cartilage. The preservation of the extracellular matrix ultrastructure of the graft makes this a promising tool for cartilage tissue engineering.
Catherine A, Bautista, Bahar, Bilgen
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Decellularizing and Recellularizing Adult Mouse Kidneys
2019Decellularization is the process by which resident cells are lysed and cellular debris is removed from the tissue, leaving behind the extracellular matrix scaffold. The extracellular matrix scaffold can be used for three-dimensional culturing of cells.
Theresa, Chow +2 more
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Characterization of CD133 Antibody-Directed Recellularized Heart Valves
Journal of Cardiovascular Translational Research, 2015CD133mAb conjugation (CD133-C) hastens in vivo recellularization of decellularized porcine heart valve scaffolds when placed in the pulmonary position of sheep. We now characterize this early cellularization process 4 h, 3, 7, 14, 30, or 90 days post-implantation.
J Koudy, Williams +5 more
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Evaluating different methods for kidney recellularization
2023End-stage renal disease (ESRD) is a condition where the kidneys fail to effectively filter waste and excess fluids from the blood. In Canada, the number of ESRD patients has increased by 24% over the past decade. While dialysis is a treatment option, kidney transplantation remains the gold standard due to higher survival rates.
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ANALYZING DECELLULARIZED AND RECELLULARIZED LIVER SCAFFOLDS USING PROTEOMICS
Cytotherapy, 2021Background Bioengineered livers are a promising approach for treating end-stage liver disease. One of the most used techniques involves decellularization, generating scaffolds that consist primarily of extracellular matrix (ECM). This ECM can be recellularized to obtain a bioartificial organ intended to mimic the native liver. Few studies focus on how
BA Paranhos +5 more
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