Results 111 to 120 of about 1,207,186 (289)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Posterity or Prosperity? Critiquing and Refiguring Prosperity Theologies in an Ecological Age
, 2015 At the beginning of the twenty-first century, prosperity theologies have simultaneously received a warm reception by some and a critical cold shoulder by others.
Swoboda, A.J.
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
La connaissance des maîtres allemands anciens en France, de Dominique-Vivant Denon à Henri Focillon
Les Cahiers de l'École du LouvreKnowledge of the old German masters, the so-called "Primitives", from the end of the 18th century to the middle of the 20th century, is the result of an immense collective effort, to which art historians, museum curators, critics and writers have all ...
Isabelle Dubois-Brinkmann +1 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Recepcja twórczości Czesława Miłosza na Litwie
Postscriptum Polonistyczne, 2020 Research on Czesław Miłosz’s works conducted in Lithuania, although not very intense, is mainly focused on the Lithuanian issues. One major trend prevails among Lithuanian researchers – an attempt to treat a substantial part of Miłosz’s works as ...
Teresa Dalecka
doaj
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Rafał Wojaczek: Advertisement in the Light of a Legend
Poznańskie Studia Polonistyczne. Seria Literacka, 2014 The article entitled “Rafał Wojaczek: Advertisement in the Light of a Legend” is the first part of a draft which tries to describe a breakthrough moment, in which the biography of Rafał Wojaczek coincides with the beginning of his literary output.
Grzegorz Pertek
doaj
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source