Results 211 to 220 of about 416,724 (298)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Who Is Watching Over the Migrant Child at Sea? [PDF]

Acta Paediatr
Corsello A.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Research on the application of refined operating room turnover efficiency in cross-hospital operating room efficiency evaluation. [PDF]

BMC Surg
Zhang C, Gong R, Yan F, Liu Y, Zang L, Pang W, Shu Y.   +6 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Teamwork and relational infrastructure: a qualitative study of modern UK general practice. [PDF]

Br J Gen Pract
Dakin FH, Meier N, Ladds E, Wieringa S, Wherton J, Rybczynska-Bunt S, Kalin A, Moore L, Greenhalgh T.   +8 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Building a One Health mobile laboratory workforce: strengthening public health preparedness across Europe and Africa. [PDF]

Hum Resour Health
Melo AM, Becker-Ziaja B, Keller M, Sangale D, Puradiredja DI, Habermann T, Bönecke J, Tomazatos A, Peham JR, Michalek B, Aasamäe A, Duscher GG, Winkelmayer L, Framke D, Schranz MT, Gleißner D, Groschup M, Haghighi F, Slowikowski P, Schwabe K, Politi L, Mellou K, Flountzi A, Dimitriadou D, Spiliopoulou I, Spanakos G, Varela A, Libenaga R, Beda M, Mgimba E, Ugolole A, Rashidi J, Munga A, Kagaruki P, Motto S, Mwafulango A, Moremi N, Mkama P, May J, Affara M, Gehre F.   +40 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Characterization of Latency Sources in a MicroPython-Based ESP32 Edge-Cloud Sensor Network. [PDF]

Sensors (Basel)
Smelcerz K.
europepmc   +1 more source