Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Theory reception: Panofsky, Kant, and disciplinary cosmopolitanism [PDF]
Journal of Art Historiography, 2009 One of the most prominent philosophical legacies in the historiography of art history is Erwin Panofsky’s debt to Immanuel Kant. Structurally and thematically, Panofsky imports philosophy, embodied by Kant, into the body of the younger discipline. I will
Mark A. Cheetham
doaj
Framing audience prefigurations of The Hobbit: An Unexpected Journey: The roles of fandom, politics and idealised intertexts [PDF]
, 2014 Audiences for blockbuster event-film sequels and adaptations often formulate highly developed expectations, motivations, understandings and opinions well before the films are released.
Davis, Charles H. +3 more
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Editor’s Introduction to the Topical Issue “Reception of the Biblical and Patristic Heritage: Case Studies and Reflections on Theory and Method” [PDF]
, 2021 Miriam De Cock
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The Transculturation of American Poetry in China, 1917-1937
, 2017 This paper offers a critical overview of the reception of American poetry in China from 1917 to 1937. Drawing on Maria Tymoczko’s theory of transculturation, it shows how in order to meet local poetic and ideological demands, America’s New Poetry ...
SONG, Chris
core
“The language of Dirac’s theory of radiation”: the inception and initial reception of a tool for the quantum field theorist [PDF]
, 2022 Markus Ehberger
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A Note on the History of European Law and Economics: Wertheim's Dissertation [PDF]
In 1930 a young Dutch scholar named W.F. Wertheim published his J.D.-dissertation Aansprakelijkheid voor schade buiten overeenkomst (Extra-contractual liability for damage).
Heico Kerkmeester
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