Results 21 to 30 of about 524,615 (248)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Transfusion‐related iron overload (TRIO) is a late effect of therapy impacting survivors of childhood cancer and hematopoietic stem cell transplantation (HSCT) who receive frequent packed red blood cell (pRBC) transfusions. Surprisingly, there are no accepted guidelines to assist providers in identifying and treating at‐risk ...
Luke Gingell +3 more
wiley +1 more source
The Reception of Hans Kelsen\u27s Legal Theory in the United States: A Sociological Model [PDF]
, 2008 The Essay explores the reasons underlying opposition to Hans Kelsen\u27s approach to the law within the U.S. legal academy. The vehemence with which legal scholars within the United States rejected Kelsen\u27s philosophy of law is best understood as a ...
Telman, D. A. Jeremy
core +1 more source
MYCN Amplification in RB1‐Inactivated Retinoblastoma: Association With High‐Risk Features
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background MYCN amplification occurs in a subset of retinoblastoma cases, both with and without RB1 inactivation. It has been suggested that retinoblastomas with MYCN amplification represent a distinct entity with more aggressive clinical behavior.
Kyriaki Papaioannou +9 more
wiley +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
The reconfiguration of Natura and Ars in cartesian rhetoric and the epistemological reflections in the prize questions of the french academies [PDF]
, 2018 This article discusses the change in the relationship between natura and ars that occurred when Cartesian language theories penetrated conceptions of rhetoric in France during the 17th century.
Urmann, Martin
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Random Matrix Theory applied to the Estimation of Collision Multiplicities [PDF]
, 2012 This paper presents two techniques in order to estimate the collision multiplicity, i.e., the number of users involved in a collision [1]. This estimation step is a key task in multi-packet reception approaches and in collision resolution techniques. The
Escrig, Benoît
core +2 more sources
Reading Joyce in and out of the Archive [PDF]
, 2007 This essay contains a critical overview of responses to the 'scholarship' (by which is meant the study of the manuscripts and notebooks, the writing of biographical, the editing of his texts, the amalgamation of annotations, etc.) as opposed to ...
Van Mierlo, Wim
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source