Results 101 to 110 of about 350,954 (315)
On the Coding of Negative Quantities in Cortical Circuits [PDF]
, 2008 Mullers Law of specific nerve energies introduced the idea that nerves transmit information about specific sensory features. This concept has been refined by the notion of 'labeled lines,' specific cells that capture sub-features of a sensory ...
Dana Ballard, Janneke Jehee
core +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Micro-probing enables fine-grained mapping of neuronal populations using fMRI
NeuroImage, 2020 The characterization of receptive field (RF) properties is fundamental to understanding the neural basis of sensory and cognitive behaviour. The combination of non-invasive imaging, such as fMRI, with biologically inspired neural modelling has enabled ...
Joana Carvalho +5 more
doaj
Cell Reports, 2018 Summary: The spike trains of retinal ganglion cells (RGCs) are the only source of visual information to the brain. Here, we genetically identify an RGC type in mice that functions as a pixel encoder and increases firing to light increments (PixON-RGC ...
Keith P. Johnson +2 more
doaj +1 more source
Infomax and Receptive Field Localization
The Brain & Neural Networks, 2002 We investigated the receptive fields of neurons in the visual cortex from a theoretical viewpoint. It was assumed that if two regions in the visual field are located far apart, local images that fall on these regions are mutually independent. An information-maximization solution was used to determine the optimal receptive field by first assuming a low ...
Hitoshi Imaoka, Kenji Okajima
openaire +3 more sources
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Journal of Neurodevelopmental Disorders, 2018 Background Sensory processing deficits are frequently co-morbid with neurodevelopmental disorders. For example, patients with fragile X syndrome (FXS), caused by a silencing of the FMR1 gene, exhibit impairments in visual function specific to the dorsal ...
Rachel B. Kay +2 more
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Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
FSRFNet: Feature-selective and Spatial Receptive Fields Networks
Applied Sciences, 2019 The attention mechanism plays a crucial role in the human visual experience. In the cognitive neuroscience community, the receptive field size of visual cortical neurons is regulated by the additive effect of feature-selective and spatial attention.
Xianghua Ma, Zhenkun Yang, Zhiqiang Yu
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