Results 101 to 110 of about 361,179 (336)

SCENet: Small Kernel Convolution with Effective Receptive Field Network for Brain Tumor Segmentation

open access: yesApplied Sciences
Brain tumors are serious conditions, which can cause great trauma to patients, endangering their health and even leading to disability or death. Therefore, accurate preoperative diagnosis is particularly important. Accurate brain tumor segmentation based
Bin Guo   +3 more
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

Computational role of eccentricity dependent cortical magnification [PDF]

open access: yes, 2014
We develop a sampling extension of M-theory focused on invariance to scale and translation. Quite surprisingly, the theory predicts an architecture of early vision with increasing receptive field sizes and a high resolution fovea -- in agreement with ...
Isik, Leyla, Mutch, Jim, Poggio, Tomaso
core   +1 more source

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

open access: yesMolecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul   +11 more
wiley   +1 more source

A Pixel-Encoder Retinal Ganglion Cell with Spatially Offset Excitatory and Inhibitory Receptive Fields

open access: yesCell Reports, 2018
Summary: The spike trains of retinal ganglion cells (RGCs) are the only source of visual information to the brain. Here, we genetically identify an RGC type in mice that functions as a pixel encoder and increases firing to light increments (PixON-RGC ...
Keith P. Johnson   +2 more
doaj   +1 more source

Visual receptive fields and clustering [PDF]

open access: yesBehavior Research Methods & Instrumentation, 1983
A pattern recognition technique—clustering—has been used to analyze and evaluate meaningful characteristics of visual receptive fields in the frog tectum. The fields were mapped either by an automatic scanning technique or by a response-feedback method called ALOPEX. The data were then analyzed by the clustering technique, which separates the receptive
openaire   +2 more sources

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

open access: yesMolecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo   +11 more
wiley   +1 more source

FSRFNet: Feature-selective and Spatial Receptive Fields Networks

open access: yesApplied Sciences, 2019
The attention mechanism plays a crucial role in the human visual experience. In the cognitive neuroscience community, the receptive field size of visual cortical neurons is regulated by the additive effect of feature-selective and spatial attention.
Xianghua Ma, Zhenkun Yang, Zhiqiang Yu
doaj   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

open access: yesMolecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez   +5 more
wiley   +1 more source

Channel Identification Machines for Multidimensional Receptive Fields

open access: yesFrontiers in Computational Neuroscience, 2014
We present algorithms for identifying multidimensional receptive fields directly from spike trains produced by biophysically-grounded neuron models.
Aurel A Lazar, Yevgeniy B. Slutskiy
doaj   +1 more source

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