Results 61 to 70 of about 350,954 (315)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Receptive Field Block Net for Accurate and Fast Object Detection

, 2018
Current top-performing object detectors depend on deep CNN backbones, such as ResNet-101 and Inception, benefiting from their powerful feature representations but suffering from high computational costs. Conversely, some lightweight model based detectors
Brian A. Wandell, D Huang, D Weng, J. R. R. Uijlings, Karen Simonyan, M Brown, Mark Everingham, Olga Russakovsky, T-Y Lin, W Liu   +9 more
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Inference of nonlinear receptive field subunits with spike-triggered clustering

eLife, 2020
Responses of sensory neurons are often modeled using a weighted combination of rectified linear subunits. Since these subunits often cannot be measured directly, a flexible method is needed to infer their properties from the responses of downstream ...
Nishal P Shah, Nora Brackbill, Colleen Rhoades, Alexandra Kling, Georges Goetz, Alan M Litke, Alexander Sher, Eero P Simoncelli, EJ Chichilnisky   +8 more
doaj   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Self-selective receptive field network for person re-identification

Complex & Intelligent Systems
Person Re-identification (Re-ID) technology aims to solve the matching problem of the same pedestrians at different times and places, which has important application value in the field of public safety.
Shaoqi Hou, Xueting liu, Chenyu Wu, Guangqiang Yin, Xinzhong Wang, Zhiguo Wang   +5 more
doaj   +1 more source

Receptive field center-surround interactions mediate context-dependent spatial contrast encoding in the retina

eLife, 2018
Antagonistic receptive field surrounds are a near-universal property of early sensory processing. A key assumption in many models for retinal ganglion cell encoding is that receptive field surrounds are added only to the fully formed center signal.
Maxwell H Turner, Gregory W Schwartz, Fred Rieke   +2 more
doaj   +1 more source

Evaluating population receptive field estimation frameworks in terms of robustness and reproducibility. [PDF]

PLoS ONE, 2014
Within vision research retinotopic mapping and the more general receptive field estimation approach constitute not only an active field of research in itself but also underlie a plethora of interesting applications.
Mario Senden, Joel Reithler, Sven Gijsen, Rainer Goebel   +3 more
doaj   +1 more source

Different Roles of Axon Guidance Cues and Patterned Spontaneous Activity in Establishing Receptive Fields in the Mouse Superior Colliculus

Frontiers in Neural Circuits, 2014
Visual neurons in the superior colliculus (SC) respond to both bright (On) and dark (off) stimuli in their receptive fields. This receptive field property is due to proper convergence of On- and Off- centered retinal ganglion cells to their target cells ...
Mingna eLiu, Lupeng eWang, Jianhua eCang
doaj   +1 more source

A Feedback Model of Attention Explains the Diverse Effects of Attention on Neural Firing Rates and Receptive Field Structure. [PDF]

PLoS Computational Biology, 2016
Visual attention has many effects on neural responses, producing complex changes in firing rates, as well as modifying the structure and size of receptive fields, both in topological and feature space.
Thomas Miconi, Rufin VanRullen
doaj   +1 more source