Results 81 to 90 of about 350,954 (315)

The Essential Complexity of Auditory Receptive Fields

PLOS Computational Biology, 2015
Encoding properties of sensory neurons are commonly modeled using linear finite impulse response (FIR) filters. For the auditory system, the FIR filter is instantiated in the spectro-temporal receptive field (STRF), often in the framework of the generalized linear model.
Ivar Thorson, Jean Liénard, Stephen V. David   +2 more
openaire   +5 more sources

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Learning Dilation Factors for Semantic Segmentation of Street Scenes

, 2017
Contextual information is crucial for semantic segmentation. However, finding the optimal trade-off between keeping desired fine details and at the same time providing sufficiently large receptive fields is non trivial. This is even more so, when objects
DE Rumelhart, GJ Brostow, M Everingham, SR Richter, T-Y Lin   +4 more
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

GaussianMix: Rethinking Receptive Field for Efficient Data Augmentation

Applied Sciences
Mixed Sample Data Augmentation (MSDA) enhances deep learning model generalization by blending a source patch into a target image. Selecting source patches based on image saliency helps to prevent label errors and irrelevant content; however, it relies on
A. F. M. Shahab Uddin, Maryam Qamar, Jueun Mun, Yuje Lee, Sung-Ho Bae   +4 more
doaj   +1 more source

Spatiotemporal receptive field structures in retinogeniculate connections of cat

Frontiers in Systems Neuroscience, 2013
The spatial structure of the receptive field (RF) of cat lateral geniculate nucleus (LGN) neurons is significantly elliptical, which may provide a basis for the orientation tuning of LGN neurons, especially at high spatial frequency stimuli. However, the
Naofumi eSuematsu, Tomoyuki eNaito, Tomomitsu eMiyoshi, Hajime eSawai, Hiromichi eSato, Hiromichi eSato   +5 more
doaj   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

A population receptive field model of the magnetoencephalography response

NeuroImage, 2021
Computational models which predict the neurophysiological response from experimental stimuli have played an important role in human neuroimaging. One type of computational model, the population receptive field (pRF), has been used to describe cortical ...
Eline R. Kupers, Akhil Edadan, Noah C. Benson, Wietske Zuiderbaan, Maartje C. de Jong, Serge O. Dumoulin, Jonathan Winawer   +6 more
doaj  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Scale-invariance of receptive field properties in primary visual cortex

BMC Neuroscience, 2007
Background Our visual system enables us to recognize visual objects across a wide range of spatial scales. The neural mechanisms underlying these abilities are still poorly understood.
Gail Alexander, Michler Frank, Wachtler Thomas, Teichert Tobias, Eckhorn Reinhard   +4 more
doaj   +1 more source