Results 111 to 120 of about 5,567,761 (311)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Motivation and L2 Receptive Vocabulary Knowledge of Spanish EFL Learners at the Official School of Languages

Miscelánea: A Journal of English and American Studies, 2014
This study explores the relationship between the motivation and receptive vocabulary knowledge of a group of 30 EFL students in the 1st and 2nd year of the Official School of Languages intermediate level (B1) (Escuela Oficial de Idiomas - EOI).
Andrés Canga Alonso, Almudena Fernández Fontecha   +1 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Risk factors for low receptive vocabulary abilities in the preschool and early school years in the longitudinal study of Australian children.

PLoS ONE, 2014
Receptive vocabulary development is a component of the human language system that emerges in the first year of life and is characterised by onward expansion throughout life.
Daniel Christensen, Stephen R Zubrick, David Lawrence, Francis Mitrou, Catherine L Taylor   +4 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The effects of receptive and productive testing on L2 active vocabulary knowledge [PDF]

Journal of Modern Research in English Language Studies
Considerable research has been conducted on the advancement of types of tests to facilitate a second language vocabulary improvement. However, whether types of tests (receptive vs.
Morteza Aslrasouli, Dariush Aliakbari, Davud Kuhi   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The effectiveness of extensive reading on EFL learners’ vocabulary learning: incidental versus intentional learning

Brazilian English Language Teaching Journal, 2015
Forty-six students majoring in business English volunteered to take part in an extensive reading program. The learners were divided into two groups: EG, the experimental group, received instruction in methods of extensive reading plus explicit output ...
Teng, Feng
doaj  

Vocabulary acquisition (incidental) through watching subtitled video material

ELT Forum: Journal of English Language Teaching, 2019
Subtitle refers to the time-synchronized text on a video that translates the spoken audio to another language. This research deals with the effect of watching subtitled video material on the vocabulary acquisition (incidental) of the Filipino learners of
Alvin Salazar Rosales
doaj   +1 more source