Results 221 to 230 of about 53,933 (241)
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Expert Opinion on Drug Discovery, 2021
Introduction The farnesoid-x-receptor (FXR) is a ubiquitously expressed nuclear receptor selectively activated by primary bile acids. Area covered FXR is a validated pharmacological target.
Stefano Fiorucci +2 more
exaly +2 more sources
Introduction The farnesoid-x-receptor (FXR) is a ubiquitously expressed nuclear receptor selectively activated by primary bile acids. Area covered FXR is a validated pharmacological target.
Stefano Fiorucci +2 more
exaly +2 more sources
Hepatology, 2021
Parenteral nutrition (PN)–associated cholestasis (PNAC) complicates the care of patients with intestinal failure. In PNAC, phytosterol containing PN synergizes with intestinal injury and IL‐1β derived from activated hepatic macrophages to suppress ...
K. E. El Kasmi +9 more
semanticscholar +1 more source
Parenteral nutrition (PN)–associated cholestasis (PNAC) complicates the care of patients with intestinal failure. In PNAC, phytosterol containing PN synergizes with intestinal injury and IL‐1β derived from activated hepatic macrophages to suppress ...
K. E. El Kasmi +9 more
semanticscholar +1 more source
Molecular Reproduction and Development, 2002
AbstractRetinoid acid receptors (RXR‐α, ‐β, ‐γ) and Farnesoid X‐activated receptor (FXR) expression in the testis of the marbled newt were investigated with special attention to the changes during the annual testicular cycle, using light microscopy immunohistochemistry and Western blot analysis. The annual testicular cycle of the marbled newt (Triturus
J M, Alfaro +6 more
openaire +2 more sources
AbstractRetinoid acid receptors (RXR‐α, ‐β, ‐γ) and Farnesoid X‐activated receptor (FXR) expression in the testis of the marbled newt were investigated with special attention to the changes during the annual testicular cycle, using light microscopy immunohistochemistry and Western blot analysis. The annual testicular cycle of the marbled newt (Triturus
J M, Alfaro +6 more
openaire +2 more sources
International Journal of Biological Macromolecules, 2020
Polysaccharides are important active constituents of Radix Puerariae lobatae (RPL). In this study, a novel homogeneous polysaccharide from RPL was successfully obtained by HP-20 macroporous resin and purified by Sepharose G-100 column chromatography ...
Y. Rao +11 more
semanticscholar +1 more source
Polysaccharides are important active constituents of Radix Puerariae lobatae (RPL). In this study, a novel homogeneous polysaccharide from RPL was successfully obtained by HP-20 macroporous resin and purified by Sepharose G-100 column chromatography ...
Y. Rao +11 more
semanticscholar +1 more source
Toxicology Mechanisms and Methods
Valproic acid (VA) is a broad-spectrum anticonvulsant agent that acts through several molecular mechanisms to control different types of seizures. The main concern of the drug is its liver toxicity. Considering the regulatory roles of the Farnesoid nuclear receptors and the nuclear transcription factor Nrf2 in modifying and neutralizing the harmful ...
Amir Saamaan, Fattahi +6 more
openaire +2 more sources
Valproic acid (VA) is a broad-spectrum anticonvulsant agent that acts through several molecular mechanisms to control different types of seizures. The main concern of the drug is its liver toxicity. Considering the regulatory roles of the Farnesoid nuclear receptors and the nuclear transcription factor Nrf2 in modifying and neutralizing the harmful ...
Amir Saamaan, Fattahi +6 more
openaire +2 more sources
Farnesoid X receptor: An important factor in blood glucose regulation
Clinica Chimica Acta, 2019Farnesoid X receptor (FXR) is a transcription factor that can be activated by bile acid as well as influenced bile acid metabolism. β-cell bile acid metabolism is mediated by FXR and closely related to the regulation of blood glucose (BG).
Yangfeng Hou, Wenjing Fan
exaly +2 more sources
The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer
Nature reviews: Gastroenterology & hepatology, 2021Lulu Sun, Jie Cai, F. Gonzalez
semanticscholar +1 more source
The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone.
Endocrinology, 2006Shuguang Wang +5 more
semanticscholar +1 more source