Results 1 to 10 of about 599,120 (337)

Clinical difference between fibroblast growth factor receptor 2 subclass, type IIIb and type IIIc, in gastric cancer [PDF]

Scientific Reports, 2021
Fibroblast growth factor receptor 2 (FGFR2) has two isoforms: IIIb type and IIIc type. Clinicopathologic significance of these two FGFR2 subtypes in gastric cancer remains to be known.
Masakazu Yashiro, Kenji Kuroda, Go Masuda, Tomohisa Okuno, Yuichiro Miki, Yurie Yamamoto, Tomohiro Sera, Atsushi Sugimoto, Shuhei Kushiyama, Sadaaki Nishimura, Shingo Togano, Masaichi Ohira   +11 more
doaj   +3 more sources

Subcellular localization of fibroblast growth factor receptor type 2 and correlation with CTNNB1 genotype in adrenocortical carcinoma [PDF]

BMC Research Notes, 2020
Objective Fibroblast growth factor receptor (FGFR) 2 regulates the development of the adrenal gland in mice. In addition, FGFR2-mediated signalling has been shown to prevent apoptosis and to enhance proliferation in adrenocortical precursor cells.
Matthias Haase, Anne Thiel, Ute I. Scholl, Hany Ashmawy, Matthias Schott, Margret Ehlers   +5 more
doaj   +6 more sources

Novel Nuclear Signaling Pathway Mediates Activation of Fibroblast Growth Factor-2 Gene by Type 1 and Type 2 Angiotensin II Receptors [PDF]

Molecular Biology of the Cell, 2001
In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF-2) gene through a unique AII-responsive promoter element. Both the type 1 and type 2 AII receptors and the downstream cyclic adenosine 1′,3′-monophosphate- and protein kinase C-dependent signaling ...
H, Peng, J, Moffett, J, Myers, X, Fang, E K, Stachowiak, P, Maher, E, Kratz, J, Hines, S J, Fluharty, E, Mizukoshi, D C, Bloom, M K, Stachowiak   +11 more
openaire   +3 more sources

PPAR? Downregulation by TGF in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis [PDF]

, 2010
The nuclear orphan receptor peroxisome proliferator-activated receptor-gamma (PPAR-γ) is expressed in multiple cell types in addition to adipocytes. Upon its activation by natural ligands such as fatty acids and eicosanoids, or by synthetic agonists such
A Galli, A Kis, A Milano, AK Ghosh, AK Ghosh, AK Ghosh, AK Ghosh, Asish K. Ghosh, BC Willis, BM Psaty, C Beyer, C Dong, Carol Feghali-Bostwick, DA Culver, ED Rosen, ED Rosen, F Verrecchia, F Zheng, G Lakos, H Ha, HA Burgess, J Berger, J Varga, J Varga, JE Milam, Jennifer L. Sargent, JL Sargent, John Varga, Joy Sturtevant, JT Tan, Jun Wei, KA Longo, Kazuhiro Komura, KM Hong, L Fajas, L Yang, LS Higgins, M Dudas, M Kapoor, M Kapoor, M Lehrke, M Trojanowska, M Wu, Manu Jain, MF Simon, Michael L. Whitfield, Minghua Wu, OA Gressner, P Karnik, P Tontonoz, Qi-Quan Huang, R Fleischmajer, S Dennler, S Kim, S Sonnylal, S Zheng, SE Ross, SH Liu, SJ Chen, SZ Duan, T Kawai, T Miyahara, T Shiomi, TM McIntyre, V Zoete, W Yuan, X Li, X Liu, X Shi-wen, X Tan, Y Mori, Y Mori, Y Park, Y Shi, Y Wang, Z Yun   +75 more
core   +21 more sources

Pivotal Role of TGF-β/Smad Signaling in Cardiac Fibrosis: Non-coding RNAs as Effectual Players

Frontiers in Cardiovascular Medicine, 2021
Unintended cardiac fibroblast proliferation in many pathophysiological heart conditions, known as cardiac fibrosis, results in pooling of extracellular matrix (ECM) proteins in the heart muscle.
Somayeh Saadat, Mahdi Noureddini, Maryam Mahjoubin-Tehran, Sina Nazemi, Layla Shojaie, Michael Aschner, Behnaz Maleki, Mohammad Abbasi-kolli, Hasan Rajabi Moghadam, Behrang Alani, Hamed Mirzaei   +10 more
doaj   +1 more source

Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway [PDF]

, 2007
BACKGROUND: Prostaglandin E(2) (PGE(2)) has been shown to modulate angiogenesis and tumour progression via the E-series prostanoid-2 (EP2) receptor. Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high ...
A.R. Williams, Abramovitz, Benard, Bendvold, Billottet, Buchanan, Davidson, Ferrandina, Giavazzi, Gupta, H.N. Jabbour, Hwang, Jaaro, Jabbour, Jabbour, Jabbour, Jeremias, K.J. Sales, Kitamura, Lumsden, Luttrell, Milling, Narumiya, Pai, Pecorelli, Perchick, Pierce, Presta, R.A. Anderson, Regan, Robertson, S. Battersby, S. Gardner, Sales, Sales, Sales, Sales, Sales, Seger, Smalley, Smith, Taylor, Templeton, Tjandrawinata, Tong, Tsujii, Vane, Woodward, Yoshida   +48 more
core   +5 more sources

Autocrine Signaling in Cardiac Remodeling: A Rich Source of Therapeutic Targets

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
The myocardium consists of different cell types, of which endothelial cells, cardiomyocytes, and fibroblasts are the most abundant. Communication between these different cell types, also called paracrine signaling, is essential for normal cardiac ...
Vincent F. M. Segers, Gilles W. De Keulenaer   +1 more
doaj   +1 more source

Overexpression of bone morphogenetic protein receptor type 2 suppresses transforming growth factor β-induced profibrotic responses in lung fibroblasts

Experimental Lung Research, 2022
Purpose of the study: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a poor prognosis. As the efficacy of currently available antifibrotics is limited, development of new therapies is warranted. Transforming growth factor (TGF)- plays a central role in the pathogenesis of IPF through mechanisms such as promoting the production of ...
Jun, Fukihara, Suzanne, Maiolo, Jessica, Kovac, Koji, Sakamoto, Keiko, Wakahara, Naozumi, Hashimoto, Paul N, Reynolds   +6 more
openaire   +2 more sources

The Antimicrobial Peptide Human β-Defensin-3 Accelerates Wound Healing by Promoting Angiogenesis, Cell Migration, and Proliferation Through the FGFR/JAK2/STAT3 Signaling Pathway

Frontiers in Immunology, 2021
In addition to its antimicrobial activity, the skin-derived antimicrobial peptide human β-defensin-3 (hBD-3) promotes keratinocyte proliferation and migration to initiate the wound healing process; however, its effects on fibroblasts, which are the major
Miho Takahashi, Miho Takahashi, Yoshie Umehara, Hainan Yue, Hainan Yue, Juan Valentin Trujillo-Paez, Ge Peng, Ge Peng, Hai Le Thanh Nguyen, Hai Le Thanh Nguyen, Risa Ikutama, Risa Ikutama, Ko Okumura, Hideoki Ogawa, Hideoki Ogawa, Shigaku Ikeda, Shigaku Ikeda, François Niyonsaba, François Niyonsaba   +18 more
doaj   +1 more source

Type 2 Fibroblast Growth Factor Receptor Signaling Preserves Stemness and Prevents Differentiation of Prostate Stem Cells from the Basal Compartment [PDF]

Journal of Biological Chemistry, 2015
Prostate stem cells (P-SCs) are capable of giving rise to all three lineages of prostate epithelial cells, which include basal, luminal, and neuroendocrine cells. Two types of P-SCs have been identified in both human and mouse adult prostates based on prostasphere or organoid cultures, cell lineage tracing, renal capsule implantation, and expression of
Yanqing, Huang, Tomoaki, Hamana, Junchen, Liu, Cong, Wang, Lei, An, Pan, You, Julia Y F, Chang, Jianming, Xu, Chengliu, Jin, Zhongying, Zhang, Wallace L, McKeehan, Fen, Wang   +11 more
openaire   +2 more sources