Melanocortin receptor accessory proteins in adrenal disease and obesity [PDF]
Frontiers in Neuroscience, 2015 Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor.
David eJackson +3 more
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Frontiers in Endocrinology, 2016 ACTH acts via a highly selective receptor that is a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors. The ACTH receptor, also known as the melanocortin 2 receptor (MC2R) is unusual in that it is absolutely dependent on ...
Adrian John Clark +6 more
doaj +5 more sources
GLP-1 Receptor Agonist Treatment in Morbid Obesity and Type 2 Diabetes Due to Pathogenic Homozygous Melanocortin-4 Receptor Mutation: A Case Report [PDF]
Cell Reports Medicine, 2020 Summary: Individuals with obesity due to pathogenic heterozygous melanocortin 4 receptor (MC4R) mutations can be treated efficiently with the glucagon-like peptide-1 receptor agonist (GLP-1 RA) liraglutide.
Eva W. Iepsen +10 more
doaj +7 more sources
Novel Melanocortin 2 Receptor Variant in a Chinese Infant With Familial Glucocorticoid Deficiency Type 1, Case Report and Review of Literature [PDF]
Frontiers in Endocrinology, 2019 Familial glucocorticoid deficiency type 1 (FGD1) is an autosomal recessive disorder caused by mutations in the melanocortin 2 receptor (MC2R) gene, characterized by a low or undetectable serum cortisol level and a high adrenocorticotropic hormone (ACTH ...
Kuerbanjiang Abuduxikuer +5 more
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Polymorphism of Melanocortin Receptor Genes—Association with Inflammatory Traits and Diseases [PDF]
DiseasesMelanocortin receptors (MCRs) are responsible for various functions ranging from skin pigmentation, regulation of appetite, stress response and cognition, steroid synthesis, and energy balance to cellular regeneration and immunomodulation.
Mainak Bardhan +12 more
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Effect of Novel Melanocortin Type 2 Receptor (MC2R) Antagonists on the Corticosterone Response to ACTH in the Neonatal Rat Adrenal Gland in vivo and in vitro. [PDF]
Frontiers in Endocrinology, 2016 Stress-induced increases in neonatal corticosterone demonstrate a unique shift from ACTH-independence to ACTH-dependence between post-natal day two (PD2) and eight (PD8) in newborn rats.
Nasha K Nensey +3 more
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Frontiers in Endocrinology, 2023 IntroductionPhysical activity is recommended as an alternative treatment for depression. Myokines, which are secreted from skeletal muscles during physical activity, play an important role in the skeletal muscle-brain axis.
Koji Ataka +4 more
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The effect of human wharton’s jelly-derived mesenchymal stem cells on MC4R, NPY, and LEPR gene expression levels in rats with streptozotocin-induced diabetes [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aimed to
Fatemeh Sabet Sarvestani +5 more
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Biology, 2022 As a member of the melanocortin receptor family, melanocortin 4 receptor (MC4R) plays a critical role in regulating energy homeostasis and feeding behavior, and has been proven as a promising therapeutic target for treating severe obesity syndrome ...
Jing Xu +8 more
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Role of melanocortin receptor accessory proteins in the function of zebrafish melanocortin receptor type 2 [PDF]
Molecular and Cellular Endocrinology, 2010 In this paper, we identify three different MRAPs in zebrafish, zfMRAP1, zfMRAP2a and zfMRAP2b, and demonstrate that zfMC2R is not functional in the absence of MRAP expression. ZfMRAP1 expression was restricted to adipose tissue and the anterior kidney whereas MRAP2a and MRAP2b were expressed in all the tissues tested. Quantification of surface receptor
Agulleiro Gozalbo, Maria Josep +5 more
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