Results 181 to 190 of about 29,683 (216)

Fibroblast growth factor 23: Regulation, signalling and systemic links between bone, metabolism and inflammation. [PDF]

Mol Metab
Crespo-Golmar A, Piñeiro-Ramil M, Pazos-Pérez A, Crugeiras-Sampedro M, Zas-Veiga L, Ait Eldjoudi D, Suárez-Rodríguez A, Jorge-Mora A, Alonso-Pérez A, Gómez R.   +9 more
europepmc   +1 more source

Cross-Expression of Thymic and Parathyroid Hormone Receptors Supports the Hypothesis of a Parathyroid-Thymus Port System. [PDF]

Int J Mol Sci
Comanescu MP, Boișteanu O, Hînganu D, Lozneanu L, Lupu FC, Grigorovici R, Grigorovici A, Lunguleac T, Hînganu MV.   +8 more
europepmc   +1 more source

Melanin concentrating hormone regulates bone cell activities and calcium metabolism in regenerating goldfish scales. [PDF]

Sci Rep
Kuroda K, Kimura S, Mizusawa K, Takahashi A, Maruyama Y, Tabuchi Y, Furusawa Y, Hirose T, Hatano K, Sakatoku A, Honda M, Matsubara H, Mishima H, Yoshida N, Srivastav AK, Hirayama J, Hattori A, Suzuki N.   +17 more
europepmc   +1 more source

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Parathyroid Hormone-Related Peptide and Parathyroid Hormone-Related Peptide Receptor Type 1 Expression in Human Lung Adenocarcinoma

Chest, 2010
In many primary tumors, parathyroid hormone-related peptide (PTHrP) and PTHrP type 1 receptor (PTH1R) are coexpressed, supporting the possibility that PTHrP/PTH1R system can mediate important signals for tumor progression through paracrine/autocrine mechanisms.
Monego, Giovanni, Lauriola, Libero, Ramella, Sara, D'Angelillo, Rolando Maria, Lanza, Paola, Granone, Pierluigi, Ranelletti, Franco Oreste   +6 more
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The Parathyroid Hormone Receptor Type 1

2020
This chapter describes the molecular and structural properties of the parathyroid hormone receptor type 1 (PTHR1), with emphasis on mechanisms of ligand binding and signal activation, as well as therapeutic applications. The basic protein architecture and mechanistic actions of the PTHR1 can now be viewed in light of the recently reported X-ray crystal
openaire   +1 more source

Calcium mobilization from fish scales is mediated by parathyroid hormone related protein via the parathyroid hormone type 1 receptor

Regulatory Peptides, 2005
The scales of bony fish represent a significant reservoir of calcium but little is known about their contribution, as well as of bone, to calcium balance and how calcium deposition and mobilization are regulated in calcified tissues. In the present study we report the action of parathyroid hormone-related protein (PTHrP) on calcium mobilization from ...
Rotllant, J., Redruello, Begoña, Guerreiro, P. M., Fernandes, H., Canario, Adelino V. M., Power, Deborah   +5 more
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β-Arrestin-biased signaling of PTH analogs of the type 1 parathyroid hormone receptor

Cellular Signalling, 2013
Parathyroid hormone (PTH) is an anabolic agent that mediates bone formation through activation of the Gα(s)-, Gα(q)- and β-arrestin-coupled parathyroid hormone receptor type 1 (PTH1R). Pharmacological evidence based on the effect of PTH(7-34), a PTH derivative that is said to preferentially activate β-arrestin signaling through PTH1R, suggests that ...
Miranda M C, van der Lee, Folkert, Verkaar, Jesse W Y, Wat, Jody, van Offenbeek, Martijn, Timmerman, Lonneke, Voorneveld, Lambertus H C J, van Lith, Guido J R, Zaman   +7 more
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Nuclear localization of the type 1 parathyroid hormone/parathyroid hormone-related peptide receptor in MC3T3-E1 cells: association with serum-induced cell proliferation

Bone, 2000
We have recently demonstrated that the receptor for parathyroid hormone (PTH) and PTH-related peptide (PTHrP), PTHR, can be localized to the nucleus of cells within the liver, kidney, uterus, gut, and ovary of the rat. We set out to determine the localization of the PTHR in cultured osteoblast-like cells.
P H, Watson, L J, Fraher, B V, Natale, M, Kisiel, G N, Hendy, A B, Hodsman   +5 more
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Endosomal signaling via cAMP in parathyroid hormone (PTH) type 1 receptor biology

Molecular and Cellular Endocrinology
Compartmentalization of GPCR signaling is an emerging topic that highlights the physiological relevance of spatial bias in signaling. The parathyroid hormone (PTH) type 1 receptor (PTH1R) was the first GPCR described to signal via heterotrimeric G-protein and cAMP from endosomes after β-arrestin mediated internalization, challenging the canonical GPCR ...
Karina A. Peña, Sofya Savransky, Breanna Lewis   +2 more
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