Results 181 to 190 of about 22,802 (228)

Modeling the hallucinatory effects of classical psychedelics in terms of replay-dependent plasticity mechanisms. [PDF]

Elife
Bredenberg C, Normandin F, Richards B, Lajoie G.   +3 more
europepmc   +1 more source

Psychedelic therapy and postpartum depression: priorities and prospects. [PDF]

Ther Adv Psychopharmacol
Thuery G, Crossen F, Mc Loone D, Hinds C, Duffy R, Jairaj C, Harkin A, Kelly JR.   +7 more
europepmc   +1 more source

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“Selective” serotonin 5-HT2A receptor antagonists

Biochemical Pharmacology, 2022
Blockade of the serotonin 5-HT2A G protein-coupled receptor (5-HT2AR) is a fundamental pharmacological characteristic of numerous antipsychotic medications, which are FDA-approved to treat schizophrenia, bipolar disorder, and as adjunctive therapies in major depressive disorder.
Austen B, Casey, Meng, Cui, Raymond G, Booth, Clinton E, Canal   +3 more
openaire   +2 more sources

EMD 281014, a new selective serotonin 5-HT2A receptor antagonist

European Journal of Pharmacology, 2003
The 5-HT2A receptor ligand 7-[4-[2-(4-fluoro-phenyl)-ethyl]-piperazine-1-carbonyl]-1H-indole-3-carbonitrile HCl (EMD 281014) selectively binds to human (h) and rat 5-HT2A receptors (IC50 values 0.35 and 1 nM, respectively; vs. 1334 nM for h5-HT2C) and inhibited 5-HT-stimulated [35S]guanosine 5'-O-3-thiotriphosphate (GTPgammaS)-accumulation in h5-HT2A ...
Gerd D, Bartoszyk, Christoph, van Amsterdam, Henning, Böttcher, Christoph A, Seyfried   +3 more
openaire   +2 more sources

Serotonin 5-HT2A Receptors: Molecular Biology and Mechanisms of Regulation

Critical Reviews™ in Neurobiology, 1998
Serotonin 5-HT2A receptors are essential for a large number of physiological functions in the central nervous system and periphery. This review article summarizes our current knowledge of the molecular biology and mechanisms of regulation of 5-HT2A receptors.
B L, Roth, S A, Berry, W K, Kroeze, D L, Willins, K, Kristiansen   +4 more
openaire   +2 more sources

Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter

Neuroscience Letters, 1999
The serotonin transporter (5-HTT) plays a key-role in the control of serotoninergic neurotransmission and is the target of some antidepressants. Possible adaptive changes in brain 5-HT2A receptors were investigated in knock-out mice that do not express the 5-HTT.
Rioux, Agnès, Fabre, Véronique, Peter Lesch, K, Moessner, Rainald, Murphy, Dennis, Lanfumey, Laurence, Hamon, Michel, Martres, Marie-Pascale   +7 more
openaire   +2 more sources

Glucocorticoid treatment increases density of serotonin 5-HT2A receptors in humans

Psychoneuroendocrinology, 2013
Interactions between the serotonergic system and the hypothalamic-pituitary-adrenal axis have been suggested, albeit the details for such interactions have yet to be established. Animal studies have shown that the density of serotonin 5-HT2A receptors is increased after administration of exogenous glucocorticoids.The objective of this study was to ...
Anders, Kling, Tom, Mjörndal, Solbritt, Rantapää-Dahlqvist   +2 more
openaire   +2 more sources

Treatment of Antipsychotic-Induced Akathisia: Role of Serotonin 5-HT2a Receptor Antagonists

Drugs, 2020
Akathisia is one of the most prevalent and distressing adverse effects associated with antipsychotic drug treatment. Propranolol, a non-selective beta-adrenergic receptor antagonist, is currently considered a first-line treatment for antipsychotic-induced akathisia (AIA). Surprisingly, the evidence for its anti-akathisia effect is modest. Propranolol's
Michael, Poyurovsky, Abraham, Weizman
openaire   +2 more sources

Adaptive mechanisms following antidepressant drugs: Focus on serotonin 5-HT2A receptors

Pharmacological Reports, 2019
There is a strong support for the role of serotonin (5-HT) neurotransmission in depression and in the mechanism of action of antidepressants. Among 5-HT receptors, 5-HT2A receptor subtype seems to be an important target implicated in the above disorder.The aim of the study was to investigate the effects of antidepressants, such as imipramine (15 mg/kg),
Dawid, Gawliński, Irena, Smaga, Magdalena, Zaniewska, Kinga, Gawlińska, Agata, Faron-Górecka, Małgorzata, Filip   +5 more
openaire   +2 more sources