Expression of Nerve Growth Factor and Its Receptor TrkA in the Reproductive System of Adult Zebrafish [PDF]
Veterinary Sciences, 2022 Nerve growth factor (NGF), a member of the neurotrophin family, has emerged as an active mediator in different crucial events in the peripheral and central nervous system.
Pietro Cacialli
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TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis. [PDF]
J Clin Invest, 2018 &NA; Receptor tyrosine kinases (RTKs) are important drivers of cancers. In addition to genomic alterations, aberrant activation of WT RTKs plays an important role in driving cancer progression.
Singh R +9 more
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The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung. [PDF]
Sci Rep, 2018 The neurotrophic tyrosine kinase receptor TrkA (NTRK1) and its ligand nerve growth factor (NGF) are emerging promoters of tumor progression. In lung cancer, drugs targeting TrkA are in clinical trials, but the clinicopathological significance of TrkA and
Gao F +10 more
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Trypanosoma cruzi coaxes cardiac fibroblasts into preventing cardiomyocyte death by activating nerve growth factor receptor TrkA. [PDF]
PLoS ONE, 2013 Cardiomyocytes express neurotrophin receptor TrkA that promotes survival following nerve growth factor (NGF) ligation. Whether TrkA also resides in cardiac fibroblasts (CFs) and underlies cardioprotection is unknown.To test whether CFs express TrkA that ...
Daniel Aridgides +2 more
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The Receptor Tyrosine Kinase TrkA Is Increased and Targetable in HER2-Positive Breast Cancer
Biomolecules, 2020 The tyrosine kinase receptor A (NTRK1/TrkA) is increasingly regarded as a therapeutic target in oncology. In breast cancer, TrkA contributes to metastasis but the clinicopathological significance remains unclear.
Nathan Griffin +7 more
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FASEB BioAdvances, 2020 Nerve growth factor (NGF) and its receptors are increasingly implicated in cancer progression, but their expression in cervical cancer is unclear. The objective of this study was to define the protein expression of NGF, its precursor (proNGF), as well as
Sam Faulkner +7 more
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Discovery of a Proteolysis Targeting Chimera for TRKA and RET-derived oncoproteins [PDF]
Scientific ReportsWe designed Proteolysis Targeting Chimeras (PROTACs) to target Tropomyosin Receptor Kinase A (TRKA) and Rearranged during Transfection (RET) oncogenic proteins.
Marialuisa Moccia +7 more
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Dynamic expression of nerve growth factor and its receptor TrkA after subarachnoid hemorrhage in rat brain [PDF]
Neural Regeneration Research, 2016 Delayed ischemic neurologic deficit after subarachnoid hemorrhage results from loss of neural cells. Nerve growth factor and its receptor TrkA may promote regeneration of neural cells, but their expression after subarachnoid hemorrhage remains unclear ...
Jin-ning Song +6 more
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International Journal of Molecular Sciences, 2017 Nerve growth factor (NGF) promotes the survival and differentiation of neurons. NGF is initially synthesized as a precursor, proNGF, which is the predominant form in the central nervous system.
Margaret Fahnestock
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Frontiers in Molecular Neuroscience, 2023 IntroductionAxonal transport of pro nerve growth factor (proNGF) is impaired in aged basal forebrain cholinergic neurons (BFCNs), which is associated with their degeneration.
Erika Kropf +5 more
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