Results 1 to 10 of about 1,768 (74)

Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75NTR

Frontiers in Molecular Neuroscience, 2023
IntroductionAxonal transport of pro nerve growth factor (proNGF) is impaired in aged basal forebrain cholinergic neurons (BFCNs), which is associated with their degeneration.
Erika Kropf, Arman Shekari, Sama Jaberi, Anish Puri, Chengbiao Wu, Margaret Fahnestock   +5 more
doaj   +1 more source

Expression of Nerve Growth Factor and Its Receptor TrkA in the Reproductive System of Adult Zebrafish

Veterinary Sciences, 2022
Nerve growth factor (NGF), a member of the neurotrophin family, has emerged as an active mediator in different crucial events in the peripheral and central nervous system.
Pietro Cacialli
doaj   +1 more source

A quest for the stereo-electronic requirements for selective agonism for the neurotrophin receptors TrkA and TrkB in 17-spirocyclic-dehydroepiandrosterone derivatives

Frontiers in Molecular Neuroscience, 2023
IntroductionThe neurotrophin system plays a pivotal role in the development, morphology, and survival of the nervous system, and its dysregulation has been manifested in numerous neurodegenerative and neuroinflammatory diseases.
Daniele Narducci, Despoina Charou, Despoina Charou, Thanasis Rogdakis, Thanasis Rogdakis, Ioanna Zota, Ioanna Zota, Vivi Bafiti, Maria Zervou, Theodora Katsila, Achille Gravanis, Achille Gravanis, Kyriakos C. Prousis, Ioannis Charalampopoulos, Ioannis Charalampopoulos, Theodora Calogeropoulou   +15 more
doaj   +1 more source

The Receptor Tyrosine Kinase TrkA Is Increased and Targetable in HER2-Positive Breast Cancer

Biomolecules, 2020
The tyrosine kinase receptor A (NTRK1/TrkA) is increasingly regarded as a therapeutic target in oncology. In breast cancer, TrkA contributes to metastasis but the clinicopathological significance remains unclear.
Nathan Griffin, Mark Marsland, Severine Roselli, Christopher Oldmeadow, John Attia, Marjorie M. Walker, Hubert Hondermarck, Sam Faulkner   +7 more
doaj   +1 more source

Enhanced TrkA signaling impairs basal forebrain-dependent behavior

Frontiers in Molecular Neuroscience, 2023
Basal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting TrkA ...
Laura Calvo-Enrique, Laura Calvo-Enrique, Silvia Lisa, Silvia Lisa, Cristina Vicente-García, Cristina Vicente-García, Ruben Deogracias, Ruben Deogracias, Juan Carlos Arévalo, Juan Carlos Arévalo   +9 more
doaj   +1 more source

Revising Berg-Purcell for finite receptor kinetics [PDF]

, 2021
From nutrient uptake, to chemoreception, to synaptic transmission, many systems in cell biology depend on molecules diffusing and binding to membrane receptors. Mathematical analysis of such systems often neglects the fact that receptors process molecules at finite kinetic rates.
arxiv   +1 more source

NGF causes TrkA to specifically attract microtubules to lipid rafts. [PDF]

PLoS ONE, 2012
Membrane protein sorting is mediated by interactions between proteins and lipids. One mechanism that contributes to sorting involves patches of lipids, termed lipid rafts, which are different from their surroundings in lipid and protein composition ...
Shona Pryor, Gretchen McCaffrey, Lindsay R Young, Mark L Grimes   +3 more
doaj   +1 more source

Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis.

PLoS Biology, 2011
The neurosteroid dehydroepiandrosterone (DHEA), produced by neurons and glia, affects multiple processes in the brain, including neuronal survival and neurogenesis during development and in aging. We provide evidence that DHEA interacts with pro-survival
Iakovos Lazaridis, Ioannis Charalampopoulos, Vassilia-Ismini Alexaki, Nicolaos Avlonitis, Iosif Pediaditakis, Paschalis Efstathopoulos, Theodora Calogeropoulou, Elias Castanas, Achille Gravanis   +8 more
doaj   +1 more source

Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma

FASEB BioAdvances, 2020
Nerve growth factor (NGF) and its receptors are increasingly implicated in cancer progression, but their expression in cervical cancer is unclear. The objective of this study was to define the protein expression of NGF, its precursor (proNGF), as well as
Sam Faulkner, Nathan Griffin, Christopher W. Rowe, Phillip Jobling, Janine M. Lombard, Sonia M. Oliveira, Marjorie M. Walker, Hubert Hondermarck   +7 more
doaj   +1 more source

Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling

eLife, 2018
The development of neurons in the peripheral nervous system is dependent on target-derived, long-range retrograde neurotrophic factor signals. The prevailing view is that target-derived nerve growth factor (NGF), the prototypical neurotrophin, and its ...
Mengchen Ye, Kathryn M Lehigh, David D Ginty   +2 more
doaj   +1 more source