Bioactive Materials, 2021 The mechanism underlying neurogenesis during embryonic spinal cord development involves a specific ligand/receptor interaction, which may be help guide neuroengineering to boost stem cell-based neural regeneration for the structural and functional repair
Ge Li, Jia-Hui Sun, Liyang Shi
exaly +3 more sources
Proneurotrophin-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons [PDF]
EMBO ReportsCancer patients undergoing treatment with antineoplastic drugs often experience chemotherapy-induced neuropathic pain (CINP), and therapeutic options for managing CINP are limited.
Dilip Sharma +7 more
doaj +2 more sources
The TrkC-PTPĪ complex governs synapse maturation and anxiogenic avoidance via synaptic protein phosphorylation [PDF]
The EMBO JournalThe precise organization of pre- and postsynaptic terminals is crucial for normal synaptic function in the brain. In addition to its canonical role as a neurotrophin-3 receptor tyrosine kinase, postsynaptic TrkC promotes excitatory synapse organization ...
Husam Khaled +14 more
doaj +2 more sources
The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS. [PDF]
PLoS ONE, 2016 Full length TrkC (TrkC-FL) is a receptor tyrosine kinase whose mRNA can be spliced to a truncated TrkC.T1 isoform lacking the kinase domain. Neurotrophin-3 (NT-3) activates TrkC-FL to maintain motor neuron health and function and TrkC.T1 to produce ...
Fouad Brahimi +13 more
doaj +6 more sources
A Small-Molecule TrkB/TrkC Ligand Promotes Neurogenesis and Behavioral Recovery Following Traumatic Brain Injury [PDF]
Neurotrauma ReportsTropomyosin receptor-kinase B (TrkB) and TrkC neurotrophin receptors promote neuronal growth and differentiation during the development and maintenance of structural integrity and plasticity in adult animals.
Jian Shi +5 more
doaj +2 more sources
Neurobiology of Disease, 2022 Degeneration of basal forebrain cholinergic neurons (BFCNs) in the nucleus basalis of Meynert (NBM) and vertical diagonal band (VDB) along with their connections is a key pathological event leading to memory impairment in Alzheimer's disease (AD ...
Tao Yang, Stephen M Massa, Frank M Longo
exaly +3 more sources
Combination of Electroacupuncture and Grafted Mesenchymal Stem Cells Overexpressing TrkC Improves Remyelination and Function in Demyelinated Spinal Cord of Rats [PDF]
Scientific Reports, 2015 10.1038/srep09133Scientific ...
Ying Ding, Bing He, Ke Zhang
exaly +4 more sources
A temporal (phospho-)proteomic dataset of neurotrophic receptor tyrosine kinase signalling in neuroblastoma [PDF]
Scientific DataNeurotrophic receptor tyrosine kinases (TrkA, TrkB, TrkC), despite their homology, contribute to the clinical heterogeneity of the childhood cancer neuroblastoma.
Stephanie Maher +3 more
doaj +2 more sources
Runx3, Brn3a and Isl1 interplay orchestrates the transcriptional program in the early stages of proprioceptive neuron development. [PDF]
PLoS GeneticsBackgroundThe development and diversification of sensory proprioceptive neurons, which reside in the dorsal root ganglia (DRG) and express the tropomyosin receptor kinase C (TrkC), depend on the transcription factor (TF) Runx3.
Kira Orlovsky +6 more
doaj +2 more sources
Expression of TrkC receptors in the developing brain of the Monodelphis opossum and its effect on the development of cortical cells. [PDF]
PLoS ONE, 2013 In this study, we investigated the distribution, localization and several various functions of TrkC receptors during development of the Monodelphisopossum brain.
Katarzyna Bartkowska +3 more
doaj +1 more source