Results 101 to 110 of about 9,033 (216)

SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development [PDF]

, 2016
Synaptogenic adhesion molecules play critical roles in synapse formation. SALM5/Lrfn5, a SALM/Lrfn family adhesion molecule implicated in autism spectrum disorders (ASDs) and schizophrenia, induces presynaptic differentiation in contacting axons, but its
Cho, Kwangwook, Choi, Yeonsoo, Jeon, Sangmin, Kim, Doyoun, Kim, Eunjoon, Kim, Ho Min, Ko, Jaewon, Kwon, Seok-Kyu, Lee, Sang-Gyu, Li, Yan, Ma, Won, Nam, Jungyong, Sung Song, Yoo, Um, Ji Won, Whitcomb, Daniel, Woo, Jooyeon   +15 more
core   +2 more sources

Role of NTRK Fusion Genes in the Tumor Immune Microenvironment of HPV (+/−) Cervical Cancer

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT Cervical cancer, a prevalent gynecological malignancy, is primarily associated with human papillomavirus (HPV) infection. However, some cases display distinct molecular alterations beyond HPV, significantly impacting the tumor immune microenvironment (TIME) and posing therapeutic challenges.
Qiongying Wang, Chan Zhang, Shijia Liu, Wangshu Li, Wenjuan Wei, Aziz ur Rehman Aziz, Han Lu, Daqing Wang   +7 more
wiley   +1 more source

TrkC Binds to the Bone Morphogenetic Protein Type II Receptor to Suppress Bone Morphogenetic Protein Signaling [PDF]

Cancer Research, 2007
Abstract TrkC, a member of the tropomyosin-related kinase (Trk) family of neurotrophin receptors, is implicated in the growth and survival of human cancer tissues. TrkC is also a potent oncoprotein expressed in tumors derived from multiple cell lineages, and functions as an active protein tyrosine kinase by neurotrophin-3 (NT-3).
Wook, Jin, Chohee, Yun, Hae-Suk, Kim, Seong-Jin, Kim   +3 more
openaire   +2 more sources

Recent advances in understanding neurotrophin signaling [version 1; referees: 2 approved]

F1000Research, 2016
The nerve growth factor family of growth factors, collectively known as neurotrophins, are evolutionarily ancient regulators with an enormous range of biological functions.
Mark Bothwell
doaj   +1 more source

Role of neurotrophins on dermal fibroblast survival and differentiation [PDF]

, 2011
Neurotrophins (NTs) belong to a family of growth factors that play a critical role in the control of skin homeostasis. NTs act through the low-affinity receptor p75NTR and the high-affinity receptors TrkA, TrkB and TrkC.
Dallaglio, Katiuscia, E., Perrier, M., Dumas, Marconi, Alessandra, P., Humbert, Palazzo, Elisabetta, Petrachi, Tiziana, Pincelli, Carlo, S., Schnebert, Truzzi, Francesca   +9 more
core   +3 more sources

Preclinical Evaluation of the Oral Toxicity, Genotoxicity, and Safety Pharmacology of LPM4870108, a Novel Potent Tropomyosin Receptor Kinase Inhibitor

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
Preclinical evaluation of the oral toxicity, genotoxicity, and safety pharmacology of LPM4870108. ABSTRACT Tropomyosin receptor kinase (Trk) inhibitors are an essential class of anticancer drugs treating NTRK gene fusions‐positive cancer. However, the potential for the emergence of on‐target resistance suggests newer Trk inhibitors with low drug ...
Xiaochen Zhang, Baiyang Yuan, Chunmei Li, Hongbo Wang, Shujuan Wei, Jingwei Tian, Sijin Duan   +6 more
wiley   +1 more source

Immunohistochemical profile of neurotrophins in human cranial dura mater and meningiomas [PDF]

, 2009
The immunohistochemical profile of neurotrophins and their receptors in the human cranial dura mater was studied by examining certain dural zones in specimens harvested from different regions (frontal, temporal, parietal and occipital).
Alicino, V, Artico, M, Bronzetti, E, D'Ambrosio, A, Elenkov, I, Fumagalli, L, Ionta, B, Pastore, FS, Pompili, E, Santoro, A   +9 more
core   +1 more source

Toward molecular phenotyping of temporal lobe epilepsy by spatial omics

Epilepsia, Volume 66, Issue 7, Page 2538-2553, July 2025.
Abstract Objective In temporal lobe epilepsy (TLE), detection of the epileptogenic zone predicts a good surgical outcome. When submitted to 18F‐fluorodeoxyglucose positron emission tomography (PET), some patients display lateralized, focal hypometabolism in the temporal lobe (PET+), whereas others appear normometabolic (PET−).
Isabeau Vermeulen, Ronny Mohren, Micca Neusinger, Tobias A. Dancker, Michiel Vandenbosch, Jan Beckervordersandforth, Benjamin Balluff, Rianna P. Van der Hel, Olaf E. M. G. Schijns, Govert Hoogland, Kim Rijkers, Berta Cillero‐Pastor, ACE epilepsy surgery group, Gwendolyn de Bruyn, Albert Colon, Jim Dings, Marc Hendriks, Danny Hilkman, Christianne Hoeberigs, Jochem van der Pol, Lotte de Jong, Kim Rijkers, Sylvia Klinkenberg, Vivianne van Kranen–Mastenbroek, Jeske Nelissen, Pieter Kubben, Walter M. Palm, Rob P. W. Rouhl, Olaf Schijns, Ilse van Straaten, Simon Tousseyn, Marielle Vlooswijk, Louis Wagner, Dorien Weckhuysen   +33 more
wiley   +1 more source

Biological background of pediatric medulloblastoma and ependymoma: A review from a translational research perspective [PDF]

, 2008
Survival rates of pediatric brain tumor patients have significantly improved over the years due to developments in diagnostic techniques, neurosurgery, chemotherapy, radiotherapy, and supportive care. However, brain tumors are still an important cause of
Boer, M.L. (Monique) den, Bont, J.M. (Judith Maria) de, Michiels, E.M.C. (Erna), Packer, R.J. (Roger), Pieters, R. (Rob)   +4 more
core   +4 more sources

Elp1 function in placode‐derived neurons is critical for proper trigeminal ganglion development

Developmental Dynamics, Volume 254, Issue 6, Page 494-512, June 2025.
Abstract Background The trigeminal nerve is the largest cranial nerve and functions in somatosensation. Cell bodies of this nerve are positioned in the trigeminal ganglion, which arises from the coalescence of neural crest and placode cells. While this dual cellular origin has been known for decades, the molecular mechanisms controlling trigeminal ...
Margaret A. Hines, Lisa A. Taneyhill
wiley   +1 more source