Results 121 to 130 of about 9,033 (216)

WITHDRAWN ARTICLE: NT-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons

EMBO Reports
Cancer patients undergoing treatment with antineoplastic drugs often experience chemotherapy-induced neuropathic pain (CINP), and the therapeutic options for managing CINP are limited. Here, we show that systemic paclitaxel administration upregulates the
Dilip Sharma, Xiaozhou Feng, Bing Wang, Bushra Yasin, Alex Bekker, Huijuan Hu, Yuan-Xiang Tao   +6 more
doaj   +1 more source

Potential effectiveness of Vitrakvi (Larotrectinib) for treating types of solid tumors carrying NTRK genes and the impact of TRKC mutations

La Granja: Revista de Ciencias de la Vida
Vitrakvi is a cancer treatment that targets solid tumors with NTRK gene fusion. NTRKs are rare genetic effects that can arise in tumors from several organs, including the lungs, thyroid glands, and intestines.
Ali Adel Dawood
doaj   +1 more source

Electroacupuncture Promotes the Differentiation of Transplanted Bone Marrow Mesenchymal Stem Cells Preinduced with Neurotrophin-3 and Retinoic Acid into Oligodendrocyte-Like Cells in Demyelinated Spinal Cord of Rats

Cell Transplantation, 2015
Transplantation of bone marrow mesenchymal stem cells (MSCs) promotes functional recovery in multiple sclerosis (MS) patients and in a murine model of MS.
Zhou Liu, Bing He, Rong-Yi Zhang, Ke Zhang, Ying Ding, Jing-Wen Ruan, Eng-Ang Ling, Jin-Lang Wu, Yuan-Shan Zeng M.D., Ph.D.   +8 more
doaj   +1 more source

Cancer immunotherapeutic targeting tropomyosin receptor kinase C (TrkC) through its conjugate and cyclophosphamide

Immunopharmacology and Immunotoxicology
Cancer cells often overexpressed specific receptors to support their proliferation and promote immunosuppressive tumor microenvironment. Tropomyosin receptor kinase C (TrkC) is known to be overexpressed in cancer, and implicated in promoting tumor progression and metastasis.
Siti Nursyahirah Bakar, Lik Voon Kiew, Lip Yong Chung, Kevin Burgess, Chin Siang Kue   +4 more
openaire   +1 more source

Distinct steps of neural induction revealed by Asterix, Obelix and TrkC, genes induced by different signals from the organizer.

PLoS ONE, 2011
The amniote organizer (Hensen's node) can induce a complete nervous system when grafted into a peripheral region of a host embryo. Although BMP inhibition has been implicated in neural induction, non-neural cells cannot respond to BMP antagonists unless ...
Sonia Pinho, Pamela R Simonsson, Katherine E Trevers, Matthew J Stower, William T Sherlock, Mohsin Khan, Andrea Streit, Guojun Sheng, Claudio D Stern   +8 more
doaj   +1 more source

Trackins (Trk-Targeting Drugs): A Novel Therapy for Different Diseases

Pharmaceuticals
Many routes may lead to the transition from a healthy to a diseased phenotype. However, there are not so many routes to travel in the opposite direction; that is, therapy for different diseases.
George N. Chaldakov, Luigi Aloe, Stanislav G. Yanev, Marco Fiore, Anton B. Tonchev, Manlio Vinciguerra, Nikolai T. Evtimov, Peter Ghenev, Krikor Dikranian   +8 more
doaj   +1 more source

Endogenous neurotrophins are required for the induction of GABAergic long-term potentiation in the neonatal rat hippocampus.

, 2005
International audienceIn the developing rat hippocampus, GABAergic synapses undergo a Ca2+-dependent long-term potentiation (LTP(GABA-A)); this form of synaptic plasticity is induced in CA3 pyramidal neurons by delivering repetitive depolarizing pulses ...
Ben-Ari, Yehezkel, Gaïarsa, Jean-Luc, Gubellini, Paolo   +2 more
core   +5 more sources

BPI-28592 as a novel second generation inhibitor for NTRK fusion tumors

npj Precision Oncology
Aberrant activation of tropomyosin receptor kinases (TRKs) is a well-defined oncogenic driver for neurotrophic tropomyosin receptor kinase (NTRK)-fusion cancers, and acquired resistant mutations have emerged with clinical use of the first-generation TRK ...
Jin Sheng, Hong Chen, Bang Fu, Hongming Pan, Jiabing Wang, Weidong Han   +5 more
doaj   +1 more source

Neurotrophin 3 (NTF3); neurotrophic tyrosine kinase receptor 3 (NTRK3; TrkC) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Entrectinib and other ALK/TRK inhibitors for the treatment of neuroblastoma

Drug Design, Development and Therapy, 2018
Holly L Pacenta, Margaret E Macy Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children’s Hospital Colorado, Aurora, CO, USA Abstract: RTK plays important roles in many cellular signaling processes involved in ...
Pacenta HL, Macy ME
doaj