Construction of a rodent neural network-skeletal muscle assembloid that simulate the postnatal development of spinal cord motor neuronal network. [PDF]
Yu H +15 more
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Mast cell activation by NGF drives the formation of trauma-induced heterotopic ossification. [PDF]
Jiang T +11 more
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A practical approach to better identify NTRK 1-3 fusion-positive mesenchymal neoplasms by pan-Trk immunohistochemistry. [PDF]
Haberecker M +5 more
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Regulation of the neuronal chloride cotransporter KCC2 by neurotrophins [PDF]
Thomas-Crusells, Judith
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Selective, Intrinsically Fluorescent Trk Modulating Probes. [PDF]
Pewklang T +5 more
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Small-Molecule Trk Agonists: Where Do We Go from Here? [PDF]
Thompson TS, Sefiani A, Burgess K.
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Whole-genome resequencing reveals the genetic diversity, population structure and selection signatures in Chinese indigenous Kele pigs. [PDF]
Zhu Y +10 more
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Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not [PDF]
Neurons of the peripheral nervous system have long been known to require survival factors to prevent their death during development. But why they selectively become dependent on secretory molecules has remained a mystery, as is the observation that in the central nervous system, most neurons do not show this dependency.
Heiko Lickert, Yves-Alain Barde
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European Journal of Medicinal Chemistry, 2022Tropomyosin receptor kinases (TRKs) are a family of TRKA, TRKB and TRKC isoforms. It has been widely reported that TRKs are implicated in a variety of tumors with several Pan-TRK inhibitors currently being used or evaluated in clinical treatment. However, off-target adverse events frequently occur in the clinical use of Pan-TRK inhibitors, which result
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