Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors.
PLoS ONE, 2014 A library of peptidomimetics was assembled combinatorially into dimers on a triazine-based core. The pharmacophore corresponds to β-turns of the neurotrophin polypeptides neurotrophin-3 (NT-3), nerve growth factor (NGF), or brain-derived neurotrophic ...
Fouad Brahimi +4 more
doaj +4 more sources
Dependence receptor TrkC is a putative colon cancer tumor suppressor. [PDF]
Proc Natl Acad Sci U S A, 2013 The TrkC neurotrophin receptor belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of their ligands. Such a trait has been hypothesized to confer tumor-suppressor activity. Indeed, cells that express these receptors are thought to be dependent on ligand availability for their ...
Genevois AL +12 more
europepmc +4 more sources
The Neurotrophin Receptor TrkC as a Novel Molecular Target of the Antineuroblastoma Action of Valproic Acid. [PDF]
Int J Mol Sci, 2021 Neurotrophins and their receptors are relevant factors in controlling neuroblastoma growth and progression. The histone deacetylase (HDAC) inhibitor valproic acid (VPA) has been shown to downregulate TrkB and upregulate the p75NTR/sortilin receptor complex. In the present study, we investigated the VPA effect on the expression of the neurotrophin-3 (NT-
Dedoni S +4 more
europepmc +5 more sources
Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder. [PDF]
Autism ResABSTRACT Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social interactions, repetitive behaviors, and hyper‐ or hyposensitivity to sensory stimuli. The cellular mechanisms underlying the emergence of abnormal sensory sensitivity in ASD are not fully understood.
Fernandez A, Sarn N, Eng C, Wright KM.
europepmc +2 more sources
Neurotrophin receptor TrkC is an entry receptor for Trypanosoma cruzi in neural, glial, and epithelial cells. [PDF]
Infect Immun, 2011 ABSTRACT Trypanosoma cruzi , the agent of Chagas' disease, infects a variety of mammalian cells in a process that includes multiple cycles of intracellular division and differentiation starting with host receptor recognition by a parasite ligand(s).
Weinkauf C, Salvador R, Pereiraperrin M.
europepmc +4 more sources
Bivalent Diketopiperazine-Based Tropomysin Receptor Kinase C (TrkC) Antagonists [PDF]
Journal of Medicinal Chemistry, 2010 Bivalent molecules containing two beta-turn mimics with side chains that correspond to hot-spots on the neurotrophin NT-3 were prepared. Binding assays showed the mimetics to be selective TrkC ligands, and biological assays showed one mimetic to be an antagonist of the TrkC receptor.
Jing, Liu +3 more
openaire +2 more sources
Proteins and signalling pathways targeted by dapagliflozin and finerenone: Insights from DAPA-CKD and FIGARO-DKD. [PDF]
Diabetes Obes MetabDiabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 750-753, January 2026.
de la Rambelje MA +4 more
europepmc +2 more sources
An ancient neurotrophin receptor code; a single Runx/Cbfβ complex determines somatosensory neuron fate specification in zebrafish. [PDF]
PLoS Genetics, 2017 In terrestrial vertebrates such as birds and mammals, neurotrophin receptor expression is considered fundamental for the specification of distinct somatosensory neuron types where TrkA, TrkB and TrkC specify nociceptors, mechanoceptors and proprioceptors/
Philia Gau +4 more
doaj +1 more source
Frontiers in Endocrinology, 2021 Neurotrophin-3 (NT3), through activation of its tropomyosin-related kinase receptor C (TrkC), modulates neuronal survival and neural stem cell differentiation.
María Bové +26 more
doaj +1 more source
The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm [PDF]
Proceedings of the National Academy of Sciences, 2007 The TrkC/NT-3 receptor/ligand pair is believed to be part of the classic neurotrophic theory claiming that neuronal death occurs by default when neurotrophic factors become limited, through loss of survival signals. Here, we show that TrkC is a dependence receptor and, as such, induces caspase-dependent apoptotic death in the absence of NT-3 in ...
Servane, Tauszig-Delamasure +8 more
openaire +2 more sources