Results 21 to 30 of about 9,033 (216)

NEUROPROTECTANT OF 7,8-DIHYDROXYFLAVONE IN ISCHEMIC STROKE THROUGH MODULATION GLUTATHIONE S-TRANSFERASE AND TYROSINE RECEPTOR KINASE C: A BIOINFORMATICS STUDY

Malang Neurology Journal, 2023
Background: Times New Roman 9, single space, contains the brief description of the research. Stroke is the greatest cause of disability and mortality worldwide.
Aldita Husna Violita, Safira Dita Arviana, Rislan Faiz Muhammad, Basyar Adnani, Titin Andri Wihastuti, Husnul Khotimah, Shahdevi Nandar Kurniawan, Yuyun Yueniwati   +7 more
doaj   +1 more source

The Dependence Receptor TrkC Triggers Mitochondria-Dependent Apoptosis upon Cobra-1 Recruitment [PDF]

Molecular Cell, 2013
The neurotrophin receptor TrkC was recently identified as a dependence receptor, and, as such, it triggers apoptosis in the absence of its ligand, NT-3. The molecular mechanism for apoptotic engagement involves the double cleavage of the receptor's intracellular domain, leading to the formation of a proapoptotic "killer" fragment (TrkC KF).
Ichim, Gabriel, Genevois, Anne-Laure, Ménard, Marie, Yu, Li-Ying, Coelho-Aguiar, Juliana m., Llambi, Fabien, Jarrosson-Wuilleme, Loraine, Lefebvre, Jonathan, Tulasne, David, Dupin, Elisabeth, Le Douarin, Nicole, Arumäe, Urmas, Tauszig-Delamasure, Servane, Mehlen, Patrick   +13 more
openaire   +2 more sources

Downregulation of TrkC Receptors Increases Dendritic Arborization of Purkinje Cells in the Developing Cerebellum of the Opossum, Monodelphis domestica

Frontiers in Neuroanatomy, 2020
In therian mammals, the cerebellum is one of the late developing structures in the brain. Specifically, the proliferation of cerebellar granule cells occurs after birth, and even in humans, the generation of these cells continues during the first year of
Beata Tepper, Katarzyna Bartkowska, Malgorzata Okrasa, Sonia Ngati, Magdalena Braszak, Krzysztof Turlejski, Ruzanna Djavadian   +6 more
doaj   +1 more source

Dual innervation of neonatal Merkel cells in mouse touch domes. [PDF]

PLoS ONE, 2014
Merkel cell-neurite complexes are specialized mechanosensory end organs that mediate discriminative touch sensation. It is well established that type I slowly adapting (SAI) mechanoreceptors, which express neural filament heavy chain (NFH), innervate ...
Jingwen Niu, Anna Vysochan, Wenqin Luo
doaj   +1 more source

Evidence for a Role of Truncated trkC Receptor Isoforms in Mouse Development [PDF]

The Journal of Neuroscience, 1999
ThetrkClocus encodes several receptors for neurotrophin-3, including the well studied full-length tyrosine kinase isoform, in addition to receptor isoforms lacking the kinase active domain. TrkC receptors are widely expressed throughout mouse development in many different organs.
M E, Palko, V, Coppola, L, Tessarollo
openaire   +2 more sources

Muscle Progenitors Derived from Extraocular Muscles Express Higher Levels of Neurotrophins and their Receptors than other Cranial and Limb Muscles [PDF]

, 2020
Extraocular muscles (EOMs) show resistance to muscle dystrophies and sarcopenia. It has been recently demonstrated that they are endowed with different types of myogenic cells, all of which present an outstanding regenerative potential. Neurotrophins are
Benítez Temiño, Beatriz, Carrero Rojas, Génova, Davis López de Carrizosa, María América, Pastor Loro, Ángel Manuel   +3 more
core   +1 more source

Differential cross-regulation of TrkA and TrkC tyrosine kinase receptors with p75 [PDF]

Oncogene, 2003
The neurotrophins neurotrophin-3 (NT-3), brain-derived growth factor (BDNF) and nerve growth factor (NGF) bind to the p75 receptor, but each neurotrophin also binds a more selective Trk receptor (e.g. TrkA-NGF and TrkC-NT-3). The biochemical signals following engagement of either Trk or p75 with ligands are well understood, but long-term biological ...
Ljubica, Ivanisevic, Kris, Banerjee, H Uri, Saragovi   +2 more
openaire   +2 more sources

Environmental enrichment reverses cerebellar impairments caused by prenatal exposure to a synthetic glucocorticoid

AIMS Neuroscience, 2022
During prenatal life, exposure to synthetic glucocorticoids (SGCs) can alter normal foetal development, resulting in disease later in life. Previously, we have shown alterations in the dendritic cytoarchitecture of Purkinje cells in adolescent rat ...
Martina Valencia , Odra Santander, Eloísa Torres, Natali Zamora, Fernanda Muñoz , Rodrigo Pascual   +5 more
doaj   +1 more source

Conversion Surgery After Administration of a TRK Inhibitor for Unresectable Parotid Gland Secretory Carcinoma. [PDF]

Head Neck
ABSTRACT Background The NTRK fusion gene is detected in most salivary gland secretory carcinomas. While tropomyosin receptor kinase (TRK) inhibitors are used for various solid tumors with the fusion gene, there are no reports regarding TRK inhibitor use for unresectable parotid gland carcinomas that subsequently shrink and become resectable.
Nagano A, Matoba T, Kawakita D, Minohara K, Iwaki S, Tsuge H, Tsukamoto K, Kikuchi S, Nakano S, Murase T, Tada Y, Iwasaki S.   +11 more
europepmc   +2 more sources

Enhancing proprioceptive input to motoneurons differentially affects expression of neurotrophin 3 and brain-derived neurotrophic factor in rat hoffmann-reflex circuitry. [PDF]

PLoS ONE, 2013
The importance of neurotrophin 3 (NT-3) for motor control prompted us to ask the question whether direct electrical stimulation of low-threshold muscle afferents, strengthening the proprioceptive signaling, could effectively increase the endogenous pool ...
Olga Gajewska-Woźniak, Małgorzata Skup, Stefan Kasicki, Ewelina Ziemlińska, Julita Czarkowska-Bauch   +4 more
doaj   +1 more source