Neural Development, 2010 The transcription factor Brn3a, product of the pou4f1 gene, is expressed in most sensory neurons throughout embryogenesis. Prior work has demonstrated a role for Brn3a in the repression of early neurogenic genes; here we describe a second major role for ...
Raisa Eng S +3 more
doaj +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S259-S306, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons. [PDF]
Genes & Development, 1996 The Trk family of protein tyrosine kinases (TrkA/B/C) are receptors for neurotrophins, a family of closely related proteins that are important physiological regulators of the survival of specific neurons within the peripheral nervous system (PNS) of vertebrates.
Minichiello, L., Klein, R.
openaire +3 more sources
Analysis of the Expression of Neurotrophins and Their Receptors in Adult Zebrafish Kidney
Veterinary Sciences, 2022 Neurotrophins and their receptors are involved in the development and maintenance of neuronal populations. Different reports have shown that all neurotrophin/receptor pathways can also play a role in several non-neuronal tissues in vertebrates, including
Pietro Cacialli, Carla Lucini
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Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis [PDF]
, 2014 Receptor protein tyrosine phosphatase sigma (RPTPσ) regulates neuronal extension and acts as a presynaptic nexus for multiple protein and proteoglycan interactions during synaptogenesis.
Aricescu, AR +9 more
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A kinase-deficient TrkC receptor isoform activates Arf6–Rac1 signaling through the scaffold protein tamalin [PDF]
The Journal of Cell Biology, 2006 Neurotrophins play an essential role in mammalian development. Most of their functions have been attributed to activation of the kinase-active Trk receptors and the p75 neurotrophin receptor. Truncated Trk receptor isoforms lacking the kinase domain are abundantly expressed during development and in the adult; however, their function and signaling ...
Esteban, Pedro F. +9 more
openaire +2 more sources
Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration [PDF]
, 2014 Introduction : The degenerate intervertebral disc (IVD) becomes innervated by sensory nerve fibres, and vascularised by blood vessels. This study aimed to identify neurotrophins, neuropeptides and angiogenic factors within native IVD tissue and to ...
Binch, Abbie L.A. +6 more
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Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo [PDF]
, 1999 The generation of sensory and autonomic neurons from the neural crest requires the functions of two classes of basic helix-loop-helix (bHLH) transcription factors, the Neurogenins (NGNs) and MASH-1, respectively (Fode, C., Gradwohl, G., Morin, X ...
Anderson, David J. +2 more
core
Target-derived neurotrophic factors regulate the death of developing forebrain neurons after a change in their trophic requirements [PDF]
, 2001 Many neurons die as the normal brain develops. How this is regulated and whether the mechanism involves neurotrophic molecules from target cells are unknown.
Asavaritikrai, P +3 more
core +1 more source
MedComm, Volume 6, Issue 10, October 2025.In TME, undetectable DCCs (panel A) join with a low tumor burden along with low immune suppression, that favor successful immune manipulation through immune suppression inhibiting immune‐therapy. This moves the immune balance toward the immune response and likely makes more stable the dormant state of DCCs in the unstable metastatic niche and/or allows
Andrea Nicolini +3 more
wiley +1 more source