Results 261 to 270 of about 214,894 (274)

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Radiolabeling and evaluation of ⁶⁴⁺⁶⁷Cu-2,2'-(1,2,4-Oxadiazole-3,5-diyl)di aniline as a theranostic agent for solid tumors. [PDF]

Sci Rep
Gizawy MA, Ayoup MS, Kodous AS, Abdelrahman MT, Motaleb MA.   +4 more
europepmc   +1 more source

Identification of TPRA1 as a Novel Receptor and Predictive Biomarker for Oncolytic Virus M1

Advanced Science, EarlyView.
This study identifies transmembrane protein adipocyte‐associated 1 (TPRA1) as a novel receptor for oncolytic virus M1 (OVM). TPRA1's ectodomain binds OVM particles, while its intracellular domain facilitates virus internalization, promoting efficient viral entry.
Linyi Hu, Guigen Zhang, Yuan Lin, Shiming Yi, Jingyu Yang, Xueying Lin, Deli Song, Zhiheng Liu, Jiayu Zhang, Ying Zeng, Shanyu Huang, Zhen Fan, Jifu Zhang, Ying Liu, Cheng Hu, Wenbo Zhu, Wei Yin, Jun Hu, Guangmei Yan, Jing Cai, Jiankai Liang   +20 more
wiley   +1 more source

A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor. [PDF]

Nat Commun
Oken AC, Turcu AL, Tzortzini E, Georgiou K, Nagel J, Westermann FG, Barniol-Xicota M, Seidler J, Kim GR, Lee SD, Nicke A, Kim YC, Müller CE, Kolocouris A, Vázquez S, Mansoor SE.   +15 more
europepmc   +1 more source

Subicular Astrocytes Govern Seizure‐Impaired Fear Memory

Advanced Science, EarlyView.
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao, Jing Xi, Yuhao Sun, Yulan Li, Zhisheng Li, Wangjialu Lu, Jialu Chen, Lin Yang, Fan Fei, Heming Cheng, Li Cheng, Cenglin Xu, Zhuo Huang, Vladimir Parpura, Yi Wang, Zhong Chen   +15 more
wiley   +1 more source

Next-Generation Proteolysis-Targeting Chimeras in Precision Oncology: Multifunctional Designs, Emerging Modalities, and Translational Prospects in Targeted Protein Degradation. [PDF]

Drug Dev Res
Nafie MS, Diab MK, Yassen ASA, Elshamy AM, El Tohamy MR, Tawfik HO, Fahmy SA.   +6 more
europepmc   +1 more source

Reciprocity in dynamics of supramolecular biosystems for the clustering of ligands and receptors. [PDF]

Proc Natl Acad Sci U S A
Dhiman S, Vleugels MEJ, Post RAJ, Crippa M, Cardellini A, Korver E, Su L, Palmans ARA, Pavan GM, van der Hofstad RW, Albertazzi L, Meijer EW.   +11 more
europepmc   +1 more source

Weighted Ensemble Simulation: Advances in methods, software, and applications. [PDF]

Wiley Interdiscip Rev Comput Mol Sci
Chong LT, Zuckerman DM.
europepmc   +1 more source

Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review. [PDF]

Adv Sci (Weinh)
Wu Q, Yan J, Zhang Y, Ming X, Chen S, Zou Z, Feng N, Xiao J.   +7 more
europepmc   +1 more source