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Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn
Science, 1991Antigen is thought to cross-link membrane-bound immunoglobulins (Igs) of B cells, causing proliferation and differentiation or the inhibition of growth. Protein tyrosine kinases are probably involved in signal transduction for cell proliferation and differentiation. The Src-like protein tyrosine kinase Lyn is expressed preferentially in B cells.
Y, Yamanashi +4 more
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Protein tyrosine kinase-mediated pathways in G protein-coupled receptor signaling
Cell Biochemistry and Biophysics, 1999Abundant evidence has indicated that protein tyrosine kinases (PTKs) convey signals from G protein-coupled receptors (GPCRs) to regulate cell proliferation, migration, adhesion, and potentially cellular transformation. Molecular mechanisms by which PTKs regulate such diverse effects in GPCR signaling are not well understood. Recently, an unifying theme
I, Dikic, A, Blaukat
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Receptor-Operated Calcium Influx Mediated by Protein Tyrosine Kinase Pathways
Journal of Receptors and Signal Transduction, 1998Calcium influx from the extracellular space elicited by activation of heterotrimeric G protein-coupled and heptahelical receptors plays a critical role in transmembrane signal transduction in a wide variety of cell systems. In nonexcitable cells, the precise voltage-independent mechanism by which calcium enters the cell remains unknown.
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Current Opinion in Cell Biology, 1991
T-cell receptor stimulation leads to a rapid increase in tyrosine phosphorylation which is regulated by both the CD45 transmembrane protein tyrosine phosphatase and by intracellular protein tyrosine kinases. The Src-family members, Fyn and Lck, have been implicated in T-cell receptor signalling and may be regulated by CD45.
A, Shaw, M L, Thomas
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T-cell receptor stimulation leads to a rapid increase in tyrosine phosphorylation which is regulated by both the CD45 transmembrane protein tyrosine phosphatase and by intracellular protein tyrosine kinases. The Src-family members, Fyn and Lck, have been implicated in T-cell receptor signalling and may be regulated by CD45.
A, Shaw, M L, Thomas
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Single-Molecule Kinetic Analysis of Receptor Protein Tyrosine Kinases
2010Signaling pathways mediated by receptor tyrosine kinases (RTKs) are among the most important pathways regulating various functions and behaviors in mammalian cells. Although many studies performed over several decades have revealed the molecular mechanisms underlying the cellular events regulated by these pathways, the overall structures of the ...
Michio Hiroshima, Yasushi Sako
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Signaling by Kit protein-tyrosine kinase—The stem cell factor receptor
Biochemical and Biophysical Research Communications, 2005Signaling by stem cell factor and Kit, its receptor, plays important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human and mouse embryonic stem cells express Kit transcripts. Stem cell factor exists as both a soluble and a membrane-bound glycoprotein while Kit is a receptor protein-tyrosine ...
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
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