Results 271 to 280 of about 396,884 (345)

Pharmacokinomic Profiling Using Patient-Derived Cell Lines Predicts Sensitivity to Imatinib in Dermatofibrosarcoma Protuberans. [PDF]

Cells
Noguchi R, Ono T, Sasaki K, Masuda M, Kawai A, Yoshimatsu Y, Kondo T.   +6 more
europepmc   +1 more source

Lenvatinib Plus Paclitaxel as Second‐Line Therapy for Advanced Gastric Cancer Patients: A Dose Escalation Exploratory Study

Advanced Science, EarlyView.
This study determines the maximum tolerated dose of lenvatinib in combination with paclitaxel as second‐line therapy for advanced gastric cancer patients. A dynamic network biomarker panel associated with patient prognosis and response to treatment is established.
Chenfei Zhou, Jinling Jiang, Liting Guo, Wenqi Xi, Junwei Wu, Qu Cai, Jun Ji, Feng Qi, Jun Zhang   +8 more
wiley   +1 more source

Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma. [PDF]

Acta Neuropathol Commun
Lin B, Shelton AK, Smithberger E, Ziebro J, Skinner KR, Bash RE, Kirkman R, Stamper A, Butler M, Flores A, Angus SP, East MP, Cloughesy TF, Nathanson DA, Berens ME, Sarkaria JN, Binder ZA, O'Rourke DM, Howton TC, Lasseigne BN, Willey CD, Johnson GL, Hjelmeland AB, Furnari FB, Miller CR.   +24 more
europepmc   +1 more source

Mechanism of activation of an ancestral Tec kinase by PIP₃

Krötenheerdt E, von Raußendorf F, Reinhardt R, Piëch L, Wedige N, Nyvall HG, Burke JE, Leonard TA.   +7 more
europepmc   +1 more source

Functional kinome profiling reveals brain protein kinase signaling pathways and gene networks altered by acute voluntary exercise in rats. [PDF]

PLoS One
Lee CM, Nguyen J, Pope B, Imami AS, Ryan VWG, Sahay S, Mathis V, Pulvender P, Eby HM, Arvay T, Alganem K, Wegman-Points L, McCullunsmith R, Yuan LL.   +13 more
europepmc   +1 more source

Tyrosine-Mediated Static and Dynamic Quenching of a Receptor Tyrosine Kinase Biosensor Reveals Inhibitor Binding Modes and Kinase Conformations. [PDF]

ACS Chem Biol
Baker ZD, Thompson AR, Thomas DD, Levinson NM.   +3 more
europepmc   +1 more source

Downregulation of kinetochore-associated 1 gene increases lagging chromosomes and contributes to chromosomal instability in gastric cancer cells. [PDF]

Med Int (Lond)
Ohsaki D, Kanayama K.
europepmc   +1 more source

Molecular insight on the role of the phosphoinositide PIP3 in regulating the protein kinases Akt, PDK1, and BTK. [PDF]

Biochem Soc Trans
Shaw AL, Burke JE.
europepmc   +1 more source

S-palmitoylation: a novel insight in the development and immunotherapy of oral squamous cell carcinoma. [PDF]

J Cancer
Yuan XT, Wang JR, Yang Y, Ren JG.
europepmc   +1 more source